Phenotypes associated with this allele

• Allele Symbol: Mob1b^{Gt(CC0690)Wtsi}
• Allele Name: gene trap CC0690, Wellcome Trust Sanger Institute
• Allele ID: MGI:3870385
• Summary: 11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mob1b^Gt(CC0690)Wtsi/Mob1b^Gt(CC0690)Wtsi	involves: 129P2/OlaHsd * C57BL/6	MGI:5473842
cn2	Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^Gt(CC0690)Wtsi/Mob1b^Gt(CC0690)Wtsi Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	B6.Cg-Mob1b^Gt(CC0690)Wtsi Mob1a^tm1.1Asuz Speer6-ps1^Tg(Alb-cre)21Mgn	MGI:5897809
cn3	Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^Gt(CC0690)Wtsi/Mob1b^Gt(CC0690)Wtsi Alb^tm1(cre/ERT2)Mtz/Alb^+	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:5897810
cn4	Ccn2^tm1.1Alea/Ccn2^tm1.1Alea Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^Gt(CC0690)Wtsi/Mob1b^Gt(CC0690)Wtsi Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA	MGI:5897813
cn5	Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^Gt(CC0690)Wtsi/Mob1b^Gt(CC0690)Wtsi Yap1^tm1c(KOMP)Mbp/Yap1^tm1c(KOMP)Mbp Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA	MGI:5897815
cn6	Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^Gt(CC0690)Wtsi/Mob1b^Gt(CC0690)Wtsi Tg(KRT14-cre/ERT)20Efu/0	involves: 129P2/OlaHsd * C57BL/6 * CD-1	MGI:5473848
cn7	Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^Gt(CC0690)Wtsi/Mob1b^Gt(CC0690)Wtsi Wwtr1^tm1Hku/Wwtr1^tm1Hku Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:5897811
cn8	Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^Gt(CC0690)Wtsi/Mob1b^Gt(CC0690)Wtsi Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+ Tgfbr2^tm1Roes/Tgfbr2^tm1Roes	involves: 129P2/OlaHsd * C57BL/6 * DBA	MGI:5897816
cx9	Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz Mob1b^Gt(CC0690)Wtsi/Mob1b^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5473843
cx10	Mob1a^tm1.2Asuz/Mob1a^+ Mob1b^Gt(CC0690)Wtsi/Mob1b^Gt(CC0690)Wtsi	involves: 129P2/OlaHsd * C57BL/6	MGI:5473844
cx11	Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz Mob1b^Gt(CC0690)Wtsi/Mob1b^Gt(CC0690)Wtsi	involves: 129P2/OlaHsd * C57BL/6	MGI:5473845

Genotype
MGI:5473842

hm1

• Allelic Composition: Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:193981 )

• mice exhibit normal morphology, body weight, histology and life span

Genotype
MGI:5897809

cn2

• Allelic Composition: Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz; Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi}; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: B6.Cg-Mob1b^{Gt(CC0690)Wtsi} Mob1a^tm1.1Asuz Speer6-ps1^{Tg(Alb-cre)21Mgn}

mortality/aging

premature death ( J:228499 )

• all mice are dead by 60 weeks

postnatal lethality, incomplete penetrance ( J:228499 )

• the first mice die at P14 and more than half of mice die by P21

liver/biliary system

liver/biliary system phenotype ( J:228499 )

N • mice exhibit normal liver structure at P0

increased hepatocyte proliferation ( J:228499 )

• 3 times in controls

abnormal cholangiocyte morphology ( J:228499 )

• at P7, mice exhibit increased immature cholangiocyte-like and oval cells that becomes massive at P10 especially in periductal and intraductal locations

• mild hepatocholangiocellular hyperplasia at P21

enlarged liver ( J:228499 )

• massive

increased hepatocyte number ( J:228499 )

• 5 times greater than in control mice at P14

liver fibrosis ( J:228499 )

increased hepatobiliary system tumor incidence ( J:228499 )

• combined hepatocellular and cholangiocarcinomas, increased hepatocellular carcinoma, liver adenoma incidence or cholangiocarcinoma in 8 of 10 mice surviving beyond P21 by age 15 weeks

• combined hepatocellular and cholangiocarcinomas in 13 of 22 mice at week 60

• with lung metastasis after 40 weeks of age

increased cholangiocarcinoma incidence ( J:228499 )

• intrahepatic cholangiocellular carcinoma in 8 of 10 mice surviving beyond P21 by age 15 weeks

• in 2 of 22 mice at week 60

increased hepatocellular carcinoma incidence ( J:228499 )

• in mice surviving beyond P21 by age 15 weeks

• in 4 of 22 mice at week 60

increased liver adenoma incidence ( J:228499 )

• in mice surviving beyond P21 by age 15 weeks

abnormal bile duct physiology ( J:228499 )

• cholangiocytes proliferation is increased 4 times compared with controls

• however, there is no increase in apoptosis

jaundice ( J:228499 )

neoplasm

increased hepatobiliary system tumor incidence ( J:228499 )

• combined hepatocellular and cholangiocarcinomas, increased hepatocellular carcinoma, liver adenoma incidence or cholangiocarcinoma in 8 of 10 mice surviving beyond P21 by age 15 weeks

• combined hepatocellular and cholangiocarcinomas in 13 of 22 mice at week 60

• with lung metastasis after 40 weeks of age

increased cholangiocarcinoma incidence ( J:228499 )

• intrahepatic cholangiocellular carcinoma in 8 of 10 mice surviving beyond P21 by age 15 weeks

• in 2 of 22 mice at week 60

increased hepatocellular carcinoma incidence ( J:228499 )

• in mice surviving beyond P21 by age 15 weeks

• in 4 of 22 mice at week 60

increased liver adenoma incidence ( J:228499 )

• in mice surviving beyond P21 by age 15 weeks

homeostasis/metabolism

increased circulating bilirubin level ( J:228499 )

integument

abdomen swellings ( J:228499 )

• due to enlarged liver

cellular

increased hepatocyte proliferation ( J:228499 )

• 3 times in controls

endocrine/exocrine glands

abnormal cholangiocyte morphology ( J:228499 )

• at P7, mice exhibit increased immature cholangiocyte-like and oval cells that becomes massive at P10 especially in periductal and intraductal locations

• mild hepatocholangiocellular hyperplasia at P21

increased cholangiocarcinoma incidence ( J:228499 )

• intrahepatic cholangiocellular carcinoma in 8 of 10 mice surviving beyond P21 by age 15 weeks

• in 2 of 22 mice at week 60

growth/size/body

enlarged liver ( J:228499 )

• massive

Genotype
MGI:5897810

cn3

• Allelic Composition: Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz; Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi}; Alb^{tm1(cre/ERT2)Mtz}/Alb⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

liver/biliary system

increased hepatobiliary system tumor incidence ( J:228499 )

• at 5 weeks, tamoxifen-treated mice exhibit milder combined hepatocellular and cholangiocarcinomas, hepatocellular carcinoma and intrahepatic cholangiocellular carcinoma compared with conditional mice with Tg(Alb-cre)21Mgn transgene

neoplasm

increased hepatobiliary system tumor incidence ( J:228499 )

• at 5 weeks, tamoxifen-treated mice exhibit milder combined hepatocellular and cholangiocarcinomas, hepatocellular carcinoma and intrahepatic cholangiocellular carcinoma compared with conditional mice with Tg(Alb-cre)21Mgn transgene

Genotype
MGI:5897813

cn4

• Allelic Composition: Ccn2^tm1.1Alea/Ccn2^tm1.1Alea; Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz; Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi}; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA

liver/biliary system

abnormal cholangiocyte morphology ( J:228499 )

• increased immature cholangiocyte-like and oval cells as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

increased liver weight ( J:228499 )

• as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

liver fibrosis ( J:228499 )

• as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

endocrine/exocrine glands

abnormal cholangiocyte morphology ( J:228499 )

• increased immature cholangiocyte-like and oval cells as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

growth/size/body

increased liver weight ( J:228499 )

• as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

Genotype
MGI:5897815

cn5

• Allelic Composition: Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz; Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi}; Yap1^{tm1c(KOMP)Mbp}/Yap1^{tm1c(KOMP)Mbp}; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA

liver/biliary system

abnormal cholangiocyte morphology ( J:228499 )

• increased immature cholangiocyte-like and oval cells but far less than in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

increased liver weight ( J:228499 )

• much less than in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

liver fibrosis ( J:228499 )

• much less than in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

endocrine/exocrine glands

abnormal cholangiocyte morphology ( J:228499 )

• increased immature cholangiocyte-like and oval cells but far less than in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

growth/size/body

increased liver weight ( J:228499 )

• much less than in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

Genotype
MGI:5473848

cn6

• Allelic Composition: Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz; Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi}; Tg(KRT14-cre/ERT)20Efu/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

Skin and hair abnormalities and large paws in tamoxifen treated Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Tg(KRT14-cre/ERT)20Efu/0 Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} mice

mortality/aging

premature death ( J:193981 )

• mice treated with tamoxifen at P28 die within 15 to 55 days of treatment

postnatal lethality, complete penetrance ( J:193981 )

• early tamoxifen-treated results in death within 10 to 30 days of birth due to malnutrition

integument

ruffled hair ( J:193981 )

• in tamoxifen-treated mice

parakeratosis ( J:193981 )

• in tamoxifen-treated mice

abnormal keratinocyte morphology ( J:193981 )

• increased centrosome number in keratinocytes from tamoxifen-treated mice

• keratinocytes from tamoxifen-treated mice exhibit multi-polar spindles unlike cells from control mice

• micronuclei in keratinocytes from tamoxifen-treated mice

epidermal hyperplasia ( J:193981 )

• at P16, tamoxifen-treated mice exhibit multilayered hyperplastic epithelium in the interfollicular epidermis and hair follicles and impaired epidermal regression during catagen unlike control mice

wrinkled skin ( J:193981 )

• wrinkle-bear facial skin in tamoxifen-treated mice

increased epidermal stem cell number ( J:193981 )

• in the interfollicular epidermis of tamoxifen-treated mice

abnormal keratinocyte physiology ( J:193981 )

• impaired contact inhibition in keratinocytes from tamoxifen-treated mice

decreased keratinocyte apoptosis ( J:193981 )

• in tamoxifen-treated mice

increased keratinocyte proliferation ( J:193981 )

• 1.5 times in tamoxifen-treated mice at P13

• keratinocyte hyperplasia in mice treated with tamoxifen at P28

cellular

abnormal cell nucleus morphology ( J:193981 )

• micronuclei in keratinocytes from tamoxifen-treated mice

abnormal mitosis ( J:193981 )

• accelerated mitotic exit in keratinocytes from tamoxifen-treated mice

abnormal mitotic spindle morphology ( J:193981 )

• keratinocytes from tamoxifen-treated mice exhibit multi-polar spindles unlike cells from control mice

decreased keratinocyte apoptosis ( J:193981 )

• in tamoxifen-treated mice

increased keratinocyte proliferation ( J:193981 )

• 1.5 times in tamoxifen-treated mice at P13

• keratinocyte hyperplasia in mice treated with tamoxifen at P28

craniofacial

abnormal mouth morphology ( J:193981 )

• tamoxifen-treated mice exhibit hyperplasia of the oral cavity unlike control mice

abnormal lip morphology ( J:193981 )

• tamoxifen-treated mice exhibit hyperplastic and enlarged lips compared with control mice

behavior/neurological

dysphagia ( J:193981 )

• in tamoxifen-treated mice

growth/size/body

abnormal mouth morphology ( J:193981 )

• tamoxifen-treated mice exhibit hyperplasia of the oral cavity unlike control mice

abnormal lip morphology ( J:193981 )

• tamoxifen-treated mice exhibit hyperplastic and enlarged lips compared with control mice

decreased body size ( J:193981 )

• in tamoxifen-treated mice

hearing/vestibular/ear

abnormal ear morphology ( J:193981 )

• tamoxifen-treated mice exhibit hyperplastic and enlarged ears compared with control mice

limbs/digits/tail

abnormal autopod morphology ( J:193981 )

• tamoxifen-treated mice exhibit hyperplastic and enlarged front paws compared with control mice

digestive/alimentary system

dysphagia ( J:193981 )

• in tamoxifen-treated mice

Genotype
MGI:5897811

cn7

• Allelic Composition: Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz; Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi}; Wwtr1^tm1Hku/Wwtr1^tm1Hku; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

liver/biliary system

abnormal cholangiocyte morphology ( J:228499 )

• increased immature cholangiocyte-like and oval cells but not as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

increased liver weight ( J:228499 )

• not as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

liver fibrosis ( J:228499 )

• not as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

endocrine/exocrine glands

abnormal cholangiocyte morphology ( J:228499 )

• increased immature cholangiocyte-like and oval cells but not as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

growth/size/body

increased liver weight ( J:228499 )

• not as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

Genotype
MGI:5897816

cn8

• Allelic Composition: Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz; Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi}; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺; Tgfbr2^tm1Roes/Tgfbr2^tm1Roes
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

liver/biliary system

abnormal cholangiocyte morphology ( J:228499 )

• increased immature cholangiocyte-like and oval cells but not as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

increased liver weight ( J:228499 )

• not as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

liver fibrosis ( J:228499 )

• not as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

endocrine/exocrine glands

abnormal cholangiocyte morphology ( J:228499 )

• increased immature cholangiocyte-like and oval cells but not as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

growth/size/body

increased liver weight ( J:228499 )

• not as much as in Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Tg(Alb-cre)21Mgn mice

Genotype
MGI:5473843

cx9

• Allelic Composition: Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz; Mob1b^{Gt(CC0690)Wtsi}/Mob1b⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Tumorgenesis in Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b⁺ or Mob1a^tm1.2Asuz/Mob1a⁺ Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} mice

neoplasm

increased salivary gland tumor incidence ( J:193981 )

• in some mice

increased liver tumor incidence ( J:193981 )

• in half of mice

increased fibrosarcoma incidence ( J:193981 )

• in myofibrosarcomas some mice

increased osteosarcoma incidence ( J:193981 )

• in some mice

increased integument system tumor incidence ( J:193981 )

• mice develop malignant outer root sheath tumors resembling trichilemmal carcinomas

increased mammary gland tumor incidence ( J:193981 )

• in some mice

increased skin tumor incidence ( J:193981 )

• in all mice

increased lung tumor incidence ( J:193981 )

• in some mice

skeleton

malocclusion ( J:193981 )

• in half of mice

increased osteosarcoma incidence ( J:193981 )

• in some mice

increased trabecular bone thickness ( J:193981 )

• in the femur of some mice

exostosis ( J:193981 )

• in the calvaria of most mice

integument

increased mammary gland tumor incidence ( J:193981 )

• in some mice

increased skin tumor incidence ( J:193981 )

• in all mice

hearing/vestibular/ear

abnormal orientation of inner hair cell stereociliary bundles ( J:193981 )

• disorganized

behavior/neurological

impaired balance ( J:193981 )

• in some mice due to disorganized inner ear hair bundles in the cochlear organ of Corti

craniofacial

malocclusion ( J:193981 )

• in half of mice

increased salivary gland tumor incidence ( J:193981 )

• in some mice

nervous system

abnormal orientation of inner hair cell stereociliary bundles ( J:193981 )

• disorganized

respiratory system

increased lung tumor incidence ( J:193981 )

• in some mice

growth/size/body

malocclusion ( J:193981 )

• in half of mice

increased salivary gland tumor incidence ( J:193981 )

• in some mice

digestive/alimentary system

increased salivary gland tumor incidence ( J:193981 )

• in some mice

endocrine/exocrine glands

increased salivary gland tumor incidence ( J:193981 )

• in some mice

increased mammary gland tumor incidence ( J:193981 )

• in some mice

liver/biliary system

increased liver tumor incidence ( J:193981 )

• in half of mice

Genotype
MGI:5473844

cx10

• Allelic Composition: Mob1a^tm1.2Asuz/Mob1a⁺; Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Tumorgenesis in Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b⁺ or Mob1a^tm1.2Asuz/Mob1a⁺ Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} mice

neoplasm

increased salivary gland tumor incidence ( J:193981 )

• in some mice

increased fibrosarcoma incidence ( J:193981 )

• in myofibrosarcomas some mice

increased osteosarcoma incidence ( J:193981 )

• in some mice

increased integument system tumor incidence ( J:193981 )

• mice develop malignant outer root sheath tumors resembling trichilemmal carcinomas

increased mammary gland tumor incidence ( J:193981 )

• in some mice

increased skin tumor incidence ( J:193981 )

• in all mice

skeleton

malocclusion ( J:193981 )

• in half of mice

increased osteosarcoma incidence ( J:193981 )

• in some mice

increased trabecular bone thickness ( J:193981 )

• in the femur of some mice

exostosis ( J:193981 )

• in the calvaria of most mice

integument

increased mammary gland tumor incidence ( J:193981 )

• in some mice

increased skin tumor incidence ( J:193981 )

• in all mice

hearing/vestibular/ear

abnormal orientation of inner hair cell stereociliary bundles ( J:193981 )

• disorganized

craniofacial

malocclusion ( J:193981 )

• in half of mice

increased salivary gland tumor incidence ( J:193981 )

• in some mice

behavior/neurological

impaired balance ( J:193981 )

• in some mice due to disorganized inner ear hair bundles in the cochlear organ of Corti

nervous system

abnormal orientation of inner hair cell stereociliary bundles ( J:193981 )

• disorganized

endocrine/exocrine glands

increased salivary gland tumor incidence ( J:193981 )

• in some mice

increased mammary gland tumor incidence ( J:193981 )

• in some mice

digestive/alimentary system

increased salivary gland tumor incidence ( J:193981 )

• in some mice

growth/size/body

malocclusion ( J:193981 )

• in half of mice

increased salivary gland tumor incidence ( J:193981 )

• in some mice

Genotype
MGI:5473845

cx11

• Allelic Composition: Mob1a^tm1.2Asuz/Mob1a^tm1.2Asuz; Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:193981 )

• despite decidua formation, mice are absorbed by E6.5

cellular

abnormal cell nucleus morphology ( J:193981 )

• micronuclei in mouse embryonic fibroblasts

abnormal mitosis ( J:193981 )

• in mouse embryonic fibroblasts

absent inner cell mass proliferation ( J:193981 )

• after 8 days in culture, E3.5 embryos exhibit growth failure of the inner cell mass

• however, the trophoectoderm develops normally

embryo

absent inner cell mass proliferation ( J:193981 )

• after 8 days in culture, E3.5 embryos exhibit growth failure of the inner cell mass

• however, the trophoectoderm develops normally