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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trip13Gt(CH0621)Wtsi
gene trap CH0621, Wellcome Trust Sanger Institute
MGI:3870635
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi involves: 129P2/OlaHsd * C57BL/6 MGI:4829840


Genotype
MGI:4829840
hm1
Allelic
Composition		 Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trip13Gt(CH0621)Wtsi mutation (0 available); any Trip13 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
impaired ovarian folliculogenesis ( J:163309 )
• devoid of follicles at 21 dpp
abnormal seminiferous tubule morphology ( J:163309 )
• less populated tubules
small testis ( J:163309 )
• mutant males have significantly smaller testes than wild-type

reproductive system
abnormal chiasmata formation ( J:163309 )
• an increased percentage of achiasmate chropmosomes are observed at pachynema in oocytes
abnormal chromosomal synapsis ( J:163309 )
• the X and Y are separated at pachynema 60-fold more often than in wild-type a 60-fold increase
arrest of male meiosis ( J:163309 )
• also arrested spermatogenesis at epithelial stage IV , but no post-meiotic cells are observed, indicating that pachytene arrest is tighter
• the numbers of crossovers and chiasmata are reduced
• the X and Y fail to form a subnuclear domain (the sex body) druing prophase compared to wild-type mice
abnormal synaptonemal complex ( J:163309 )
• proper pachynema with fully synapsed autosomal bivalents are never observed
impaired ovarian folliculogenesis ( J:163309 )
• devoid of follicles at 21 dpp
abnormal seminiferous tubule morphology ( J:163309 )
• less populated tubules
small testis ( J:163309 )
• mutant males have significantly smaller testes than wild-type

cellular
abnormal chiasmata formation ( J:163309 )
• an increased percentage of achiasmate chropmosomes are observed at pachynema in oocytes
abnormal chromosomal synapsis ( J:163309 )
• the X and Y are separated at pachynema 60-fold more often than in wild-type a 60-fold increase
arrest of male meiosis ( J:163309 )
• also arrested spermatogenesis at epithelial stage IV , but no post-meiotic cells are observed, indicating that pachytene arrest is tighter
• the numbers of crossovers and chiasmata are reduced
• the X and Y fail to form a subnuclear domain (the sex body) druing prophase compared to wild-type mice
abnormal synaptonemal complex ( J:163309 )
• proper pachynema with fully synapsed autosomal bivalents are never observed




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory