About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trip13Gt(CH0621)Wtsi
gene trap CH0621, Wellcome Trust Sanger Institute
MGI:3870635
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi involves: 129P2/OlaHsd * C57BL/6 MGI:4829840


Genotype
MGI:4829840
hm1
Allelic
Composition		 Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trip13Gt(CH0621)Wtsi mutation (0 available); any Trip13 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
impaired ovarian folliculogenesis ( J:163309 )
• devoid of follicles at 21 dpp
abnormal seminiferous tubule morphology ( J:163309 )
• less populated tubules
small testis ( J:163309 )
• mutant males have significantly smaller testes than wild-type

reproductive system
abnormal chiasmata formation ( J:163309 )
• an increased percentage of achiasmate chropmosomes are observed at pachynema in oocytes
abnormal chromosomal synapsis ( J:163309 )
• the X and Y are separated at pachynema 60-fold more often than in wild-type a 60-fold increase
arrest of male meiosis ( J:163309 )
• also arrested spermatogenesis at epithelial stage IV , but no post-meiotic cells are observed, indicating that pachytene arrest is tighter
• the numbers of crossovers and chiasmata are reduced
• the X and Y fail to form a subnuclear domain (the sex body) druing prophase compared to wild-type mice
abnormal synaptonemal complex ( J:163309 )
• proper pachynema with fully synapsed autosomal bivalents are never observed
impaired ovarian folliculogenesis ( J:163309 )
• devoid of follicles at 21 dpp
abnormal seminiferous tubule morphology ( J:163309 )
• less populated tubules
small testis ( J:163309 )
• mutant males have significantly smaller testes than wild-type

cellular
abnormal chiasmata formation ( J:163309 )
• an increased percentage of achiasmate chropmosomes are observed at pachynema in oocytes
abnormal chromosomal synapsis ( J:163309 )
• the X and Y are separated at pachynema 60-fold more often than in wild-type a 60-fold increase
arrest of male meiosis ( J:163309 )
• also arrested spermatogenesis at epithelial stage IV , but no post-meiotic cells are observed, indicating that pachytene arrest is tighter
• the numbers of crossovers and chiasmata are reduced
• the X and Y fail to form a subnuclear domain (the sex body) druing prophase compared to wild-type mice
abnormal synaptonemal complex ( J:163309 )
• proper pachynema with fully synapsed autosomal bivalents are never observed




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory