Phenotypes associated with this allele

• Allele Symbol: Gas8^{Gt(CH0760)Wtsi}
• Allele Name: gene trap CH0760, Wellcome Trust Sanger Institute
• Allele ID: MGI:3870680
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gas8^Gt(CH0760)Wtsi/Gas8^Gt(CH0760)Wtsi	involves: 129P2/OlaHsd * C57BL/6	MGI:5803879
ht2	Gas8^Gt(CH0760)Wtsi/Gas8^em1Bky	involves: 129P2/OlaHsd * C57BL/6	MGI:5803880

Genotype
MGI:5803879

hm1

• Allelic Composition: Gas8^{Gt(CH0760)Wtsi}/Gas8^{Gt(CH0760)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:234173 )

• most mice die by P14 with few living mice at P21

growth/size/body

right-sided stomach ( J:234173 )

• in 6 of 16 live born mice

situs inversus with levocardia ( J:234173 )

• in 6 of 16 live born mice based on stomach and heart position

respiratory system

abnormal respiratory motile cilium physiology ( J:234173 )

• decreased beat frequency

abnormal tracheal ciliated epithelium morphology ( J:234173 )

• broken doublet rings and disorganized arrangement of microtubule doublets in some cilia with dyskinesia

• short cilia

nervous system

abnormal brain ependyma motile cilium physiology ( J:234173 )

• decreased beat frequency

hydrocephaly ( J:234173 )

• severe

cellular

abnormal brain ependyma motile cilium physiology ( J:234173 )

• decreased beat frequency

abnormal respiratory motile cilium physiology ( J:234173 )

• decreased beat frequency

digestive/alimentary system

right-sided stomach ( J:234173 )

• in 6 of 16 live born mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary ciliary dyskinesia 33		DOID:0110619	OMIM:616726	J:234173

Genotype
MGI:5803880

ht2

• Allelic Composition: Gas8^{Gt(CH0760)Wtsi}/Gas8^em1Bky
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

hydrocephaly ( J:234173 )

• mild to moderate at 10 weeks of age

growth/size/body

growth/size/body region phenotype ( J:234173 )

N • mice do not exhibit laterality defects

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary ciliary dyskinesia 33		DOID:0110619	OMIM:616726	J:234173