Phenotypes associated with this allele

• Allele Symbol: Klf3^{Gt(CH0516)Wtsi}
• Allele Name: gene trap CH0516, Wellcome Trust Sanger Institute
• Allele ID: MGI:3872001
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klf3^Gt(CH0516)Wtsi/Klf3^Gt(CH0516)Wtsi	involves: 129P2/OlaHsd * C57BL/6	MGI:5568084
ht2	Klf3^Gt(CH0516)Wtsi/Klf3^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5568085

Genotype
MGI:5568084

hm1

• Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Enlarged right ventricle and pulmonary valve regurgitation in Klf3^{Gt(CH0516)Wtsi}/Klf3^{Gt(CH0516)Wtsi} mice

mortality/aging

preweaning lethality, incomplete penetrance ( J:206507 )

• fewer than expected mice are present at weaning

cardiovascular system

cardiovascular system phenotype ( J:206507 )

N • unlike mice heterozygous for an ENU-induce allele, mice do not exhibit septal defects

increased heart left atrium size ( J:206507 )

• increased left atrial area

increased heart right atrium size ( J:206507 )

• increased right atrial area

increased heart weight ( J:206507 )

abnormal heart left ventricle morphology ( J:206507 )

• increased left ventricle end diastolic volume

increased heart right ventricle size ( J:206507 )

• in 6 of 8 mice

abnormal blood flow velocity ( J:206507 )

• increased peak velocity in ascending aorta and pulmonary artery

• increased right ventricular E-wave

increased cardiac output ( J:206507 )

tricuspid valve regurgitation ( J:206507 )

pulmonary valve regurgitation ( J:206507 )

• in 8 of 8 mice

decreased mean systemic arterial blood pressure ( J:206507 )

hematopoietic system

hematopoietic system phenotype ( J:206507 )

N • unlike mice heterozygous for an ENU-induce allele, mice exhibit normal red blood cell counts and hemoglobin concentration

increased spleen weight ( J:206507 )

increased red blood cell distribution width ( J:206507 )

increased leukocyte cell number ( J:206507 )

reticulocytosis ( J:206507 )

adipose tissue

decreased abdominal fat pad weight ( J:206507 )

growth/size/body

increased heart weight ( J:206507 )

decreased body weight ( J:206507 )

increased kidney weight ( J:206507 )

increased lung weight ( J:206507 )

increased liver weight ( J:206507 )

increased spleen weight ( J:206507 )

liver/biliary system

increased liver weight ( J:206507 )

nervous system

increased brain weight ( J:206507 )

renal/urinary system

increased kidney weight ( J:206507 )

respiratory system

increased lung weight ( J:206507 )

immune system

increased spleen weight ( J:206507 )

increased leukocyte cell number ( J:206507 )

Genotype
MGI:5568085

ht2

• Allelic Composition: Klf3^{Gt(CH0516)Wtsi}/Klf3⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

mortality/aging ( J:206507 )

N • unlike mice heterozygous for an ENU-induce allele, mice exhibit normal survival