Phenotypes associated with this allele

• Allele Symbol: Cdk7^{Gt(D032B11)Wrst}
• Allele Name: gene trap D032B11, German Gene Trap Consortium
• Allele ID: MGI:3873807
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk7^Gt(D032B11)Wrst/Cdk7^Gt(D032B11)Wrst	involves: 129S2/SvPas	MGI:5429240

Genotype
MGI:5429240

hm1

• Allelic Composition: Cdk7^{Gt(D032B11)Wrst}/Cdk7^{Gt(D032B11)Wrst}
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:183925 )

• die during peri-implantation stages

embryo

abnormal inner cell mass apoptosis ( J:183925 )

• cultured E2.5 embryos show high levels of apoptosis in the inner cell mass at E4.5 leading to absence of the inner cell mass 2 days later in hatching embryos

increased embryonic tissue cell apoptosis ( J:183925 )

• at E5.5 deciduas with a high percentage of apoptotic cells within the embryonic body are seen

abnormal trophoblast layer morphology ( J:183925 )

• E2.5 embryos cultured until E6.5-E7.5 contain trophoblast cells with smaller nuclei

cellular

abnormal inner cell mass apoptosis ( J:183925 )

• cultured E2.5 embryos show high levels of apoptosis in the inner cell mass at E4.5 leading to absence of the inner cell mass 2 days later in hatching embryos

increased embryonic tissue cell apoptosis ( J:183925 )

• at E5.5 deciduas with a high percentage of apoptotic cells within the embryonic body are seen