Phenotypes associated with this allele

• Allele Symbol: Tpx2^{Gt(D028B03)Wrst}
• Allele Name: gene trap D028B03, German Gene Trap Consortium
• Allele ID: MGI:3873923
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tpx2^Gt(D028B03)Wrst/Tpx2^Gt(D028B03)Wrst	involves: 129S2/SvPas * C57BL/6J	MGI:5426864
ht2	Tpx2^Gt(D028B03)Wrst/Tpx2^+	involves: 129S2/SvPas * C57BL/6J	MGI:5426865

Genotype
MGI:5426864

hm1

• Allelic Composition: Tpx2^{Gt(D028B03)Wrst}/Tpx2^{Gt(D028B03)Wrst}
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:184948 )

• mice die between E1.5 and E8.5

embryo

abnormal embryo development ( J:184948 )

• cultured E1.5 cells fail to establish a proper bipolar spindle unlike wild-type cells

embryonic growth arrest ( J:184948 )

• arrested at morula stage

cellular

polyploidy ( J:184948 )

• tetraploid cells are observed in cultured E1.5 embryos

abnormal mitotic spindle morphology ( J:184948 )

• cultured E1.5 cells fail to establish a proper bipolar spindle unlike wild-type cells

Genotype
MGI:5426865

ht2

• Allelic Composition: Tpx2^{Gt(D028B03)Wrst}/Tpx2⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

neoplasm

increased intestinal adenoma incidence ( J:184948 )

increased stomach tumor incidence ( J:184948 )

• stomach carcinoma

increased hepatocellular carcinoma incidence ( J:184948 )

increased metastatic potential ( J:184948 )

• high aggressiveness to brain and heart

increased lung adenoma incidence ( J:184948 )

• alveolar type II cell adenomas and adenocarcinomas

increased lymphoma incidence ( J:184948 )

increased lung adenocarcinoma incidence ( J:184948 )

• alveolar type II cell adenomas and adenocarcinomas

cellular

aneuploidy ( J:184948 )

• high grade aneuploidy in splenocytes

• in tumors

endocrine/exocrine glands

pituitary intermediate lobe hyperplasia ( J:184948 )

immune system

abnormal splenocyte morphology ( J:184948 )

• high grade aneuploidy in splenocytes

granulomatous inflammation ( J:184948 )

• hypogranuloma

nervous system

pituitary intermediate lobe hyperplasia ( J:184948 )

hematopoietic system

abnormal splenocyte morphology ( J:184948 )

• high grade aneuploidy in splenocytes

liver/biliary system

increased hepatocellular carcinoma incidence ( J:184948 )

digestive/alimentary system

increased intestinal adenoma incidence ( J:184948 )

increased stomach tumor incidence ( J:184948 )

• stomach carcinoma

respiratory system

increased lung adenoma incidence ( J:184948 )

• alveolar type II cell adenomas and adenocarcinomas

increased lung adenocarcinoma incidence ( J:184948 )

• alveolar type II cell adenomas and adenocarcinomas