Phenotypes associated with this allele

• Allele Symbol: Stag1^{Gt(P099A04)Wrst}
• Allele Name: gene trap P099A04, German Gene Trap Consortium
• Allele ID: MGI:3874033
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stag1^Gt(P099A04)Wrst/Stag1^Gt(P099A04)Wrst	involves: 129S2/SvPas	MGI:5446709
ht2	Stag1^Gt(P099A04)Wrst/Stag1^+	involves: 129S2/SvPas	MGI:5446710

Genotype
MGI:5446709

hm1

• Allelic Composition: Stag1^{Gt(P099A04)Wrst}/Stag1^{Gt(P099A04)Wrst}
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:184720 )

• no newborn mice are recovered

embryonic lethality during organogenesis, incomplete penetrance ( J:184720 )

• mice die between E11.5 and E12.5 with some surviving to E18.5

cellular

aneuploidy ( J:184720 )

• in mouse embryonic fibroblasts

abnormal telomere morphology ( J:184720 )

• fragile telomeres with defective telomere replication

abnormal mitosis ( J:184720 )

• defective chromosome segregation in mouse embryonic fibroblasts

decreased cell proliferation ( J:184720 )

• in cells from E18.5 embryos

decreased fibroblast proliferation ( J:184720 )

growth/size/body

abnormal tooth development ( J:184719 )

• delay in dendition at E17.5

decreased fetal size ( J:184719 , J:184720 )

• at E17.5 (J:184719)

• in cells from E18.5 embryos (J:184720)

adipose tissue

decreased brown adipose tissue amount ( J:184719 )

• reduced thickness at E17.5

decreased total body fat amount ( J:184719 )

• at E17.5

craniofacial

abnormal tooth development ( J:184719 )

• delay in dendition at E17.5

hematopoietic system

abnormal definitive hematopoiesis ( J:184719 )

• decreased number of hematopoietic precursors in the liver at E17.5

integument

decreased hair follicle number ( J:184719 )

• at E17.5

thin skin ( J:184719 )

• at E17.5

muscle

abnormal muscle morphology ( J:184719 )

• thin muscle layer at E17.5

renal/urinary system

abnormal kidney collecting duct morphology ( J:184719 )

• not radially arranged at E17.5

abnormal renal glomerulus morphology ( J:184719 )

• at E17.5, glomeruli are dispersed all over unlike in wild-type mice

skeleton

abnormal tooth development ( J:184719 )

• delay in dendition at E17.5

abnormal bone mineralization ( J:184719 )

• defective bone calcification in the cranium at E17.5

delayed intramembranous bone ossification ( J:184719 )

• in the cranium at E17.5

Genotype
MGI:5446710

ht2

• Allelic Composition: Stag1^{Gt(P099A04)Wrst}/Stag1⁺
• Genetic Background: involves: 129S2/SvPas

mortality/aging

premature death ( J:184720 )

premature aging ( J:184720 )

• some symptoms of premature aging including acute kyphosis

neoplasm

decreased incidence of tumors by chemical induction ( J:184720 )

• mice are resistant to 3-methyl-colanthrene-induced fibrosarcomas and diethyl-nitrosamine-induced liver tumors

decreased tumor growth/size ( J:184720 )

• reduced cell proliferation in 3-methyl-colanthrene-induced fibrosarcomas

increased tumor incidence ( J:184720 )

• reduced latency and altered tumor spectrum

• tumor incidence is not altered in Trp53 or Pten null backgrounds

increased lymphoma incidence ( J:184720 )

increased histiocytic sarcoma incidence ( J:184720 )

increased carcinoma incidence ( J:184720 )

• hepatocellular carcinoma and vascular carcinomas

increased hepatocellular carcinoma incidence ( J:184720 )

increased papilloma incidence ( J:184720 )

• cystic papillary neoplasm in the pancreas

cellular

abnormal telomere morphology ( J:184720 )

• intermediate fragile telomeres with defective telomere replication

abnormal mitosis ( J:184720 )

• increased frequency od defective anaphase in mouse embryonic fibroblasts and issues

decreased cell proliferation ( J:184720 )

• reduced cell proliferation in 3-methyl-colanthrene-induced fibrosarcomas

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:184720 )

• mice are resistant to 3-methyl-colanthrene-induced fibrosarcomas and diethyl-nitrosamine-induced liver tumors

skeleton

kyphosis ( J:184720 )

• acute

liver/biliary system

increased hepatocellular carcinoma incidence ( J:184720 )