Phenotypes associated with this allele

• Allele Symbol: Nanog^{Gt(D047A12)Wrst}
• Allele Name: gene trap D047A12, German Gene Trap Consortium
• Allele ID: MGI:3874467
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nanog^Gt(D047A12)Wrst/Nanog^Gt(D047A12)Wrst	involves: 129S2/SvPas * C57BL/6	MGI:4822578

Genotype
MGI:4822578

hm1

• Allelic Composition: Nanog^{Gt(D047A12)Wrst}/Nanog^{Gt(D047A12)Wrst}
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:163559 )

• mice die between E4.5 and E7.5

embryo

abnormal inner cell mass apoptosis ( J:163559 )

• at E4.5, the inner cell mass exhibits an increase in apoptosis compared to in wild-type mice

absent primitive endoderm ( J:163559 )

• mice do not develop primitive endoderm

• however, primitive endoderm will form when cells are used to generate a chimeric embryo

abnormal inner cell mass morphology ( J:163559 )

• at E4.5, the number of inner cell mass cells is decreased compared to in wild-type mice

cellular

abnormal inner cell mass apoptosis ( J:163559 )

• at E4.5, the inner cell mass exhibits an increase in apoptosis compared to in wild-type mice