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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trim71Gt(H004C06)Wrst
gene trap H004C06, German Gene Trap Consortium
MGI:3875666
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trim71Gt(H004C06)Wrst/Trim71Gt(H004C06)Wrst B6J.129S2-Trim71Gt(H004C06)Wrst MGI:5706987
ht2
 		Trim71Gt(H004C06)Wrst/Trim71+ B6J.129S2-Trim71Gt(H004C06)Wrst MGI:5706988


Genotype
MGI:5706987
hm1
Allelic
Composition		 Trim71Gt(H004C06)Wrst/Trim71Gt(H004C06)Wrst
Genetic
Background		 B6J.129S2-Trim71Gt(H004C06)Wrst
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim71Gt(H004C06)Wrst mutation (0 available); any Trim71 mutation (170 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:226960 )
• homozygotes die shortly after E9.5, often encapsulated and undergoing reabsorption by E12.5

embryo
embryonic growth arrest ( J:226960 )
• homozygotes stop developing at ~E9.5
incomplete rostral neuropore closure ( J:226960 )
• at E9.5, homozygotes show a highly penetrant closure defect in the anterior craniofacial region of the neural tube, at the level of the forebrain/midbrain boundary
• however, the spinal cord and rostral extremity of the forebrain appear unaffected

nervous system
incomplete rostral neuropore closure ( J:226960 )
• at E9.5, homozygotes show a highly penetrant closure defect in the anterior craniofacial region of the neural tube, at the level of the forebrain/midbrain boundary
• however, the spinal cord and rostral extremity of the forebrain appear unaffected




Genotype
MGI:5706988
ht2
Allelic
Composition		 Trim71Gt(H004C06)Wrst/Trim71+
Genetic
Background		 B6J.129S2-Trim71Gt(H004C06)Wrst
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trim71Gt(H004C06)Wrst mutation (0 available); any Trim71 mutation (170 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:226960 )
• heterozygotes are viable, fertile and do not exhibit any apparent phenotype, size change or other abnormality relative to wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory