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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kif13bGt(AF0005)Wtsi
gene trap AF0005, Wellcome Trust Sanger Institute
MGI:3876683
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kif13bGt(AF0005)Wtsi/Kif13bGt(AF0005)Wtsi involves: 129P2/OlaHsd * C57BL/6J MGI:6385206
cx2
 		Kif13aGt(AF0553)Wtsi/Kif13aGt(AF0553)Wtsi
Kif13bGt(AF0005)Wtsi/Kif13bGt(AF0005)Wtsi 		involves: 129P2/OlaHsd * C57BL/6J MGI:6385207


Genotype
MGI:6385206
hm1
Allelic
Composition		 Kif13bGt(AF0005)Wtsi/Kif13bGt(AF0005)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif13bGt(AF0005)Wtsi mutation (1 available); any Kif13b mutation (109 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating HDL cholesterol level ( J:282570 )
• mice show relatively increased HDL levels

cellular
abnormal fibroblast physiology ( J:282570 )
• MEFs show reduced uptake of LDL without disruption of hydrolysis




Genotype
MGI:6385207
cx2
Allelic
Composition		 Kif13aGt(AF0553)Wtsi/Kif13aGt(AF0553)Wtsi
Kif13bGt(AF0005)Wtsi/Kif13bGt(AF0005)Wtsi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif13aGt(AF0553)Wtsi mutation (0 available); any Kif13a mutation (105 available)
Kif13bGt(AF0005)Wtsi mutation (1 available); any Kif13b mutation (109 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:282570 )
• high mortality after birth, with most newborn pups either dead or cannibalized and occasionally newborn pups are found dead at day 1

behavior/neurological
absent gastric milk in neonates ( J:282570 )
• pups that die at day 1 have stomachs filled with air without any milk

craniofacial
short snout ( J:282570 )
• dead pups exhibit a short nose

growth/size/body
short snout ( J:282570 )
• dead pups exhibit a short nose




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory