Phenotypes associated with this allele

• Allele Symbol: Uty^{Gt(XS0378)Wtsi}
• Allele Name: gene trap XS0378, Wellcome Trust Sanger Institute
• Allele ID: MGI:3877328
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Kdm6a^Gt(RRA094)Byg/Y X/Uty^Gt(XS0378)Wtsi	either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)	MGI:5516061
ot2	X/Uty^Gt(XS0378)Wtsi	either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)	MGI:5516068

Genotype
MGI:5516061

cx1

• Allelic Composition: Kdm6a^{Gt(RRA094)Byg}/Y; X/Uty^{Gt(XS0378)Wtsi}
• Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:201868 )

♂ • no mice recovered at E18.5

♂ • found at expected ratios at E10.5

cardiovascular system

abnormal heart morphology ( J:201868 )

♂

failure of heart looping ( J:201868 )

♂ • incomplete

thin interventricular septum ( J:201868 )

♂ • poorly formed and incomplete

small heart ( J:201868 )

♂

myocardial trabeculae hypoplasia ( J:201868 )

♂

thin ventricular wall ( J:201868 )

♂

pericardial edema ( J:201868 )

♂ • in more severe cases

homeostasis/metabolism

pericardial edema ( J:201868 )

♂ • in more severe cases

muscle

myocardial trabeculae hypoplasia ( J:201868 )

♂

Genotype
MGI:5516068

ot2

• Allelic Composition: X/Uty^{Gt(XS0378)Wtsi}
• Genetic Background: either: (involves: 129 * CD-1) or (involves: 129P2/OlaHsd * CD-1) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

normal phenotype

no abnormal phenotype detected ( J:201868 )

♂ • mice are viable and fertile