Phenotypes associated with this allele

• Allele Symbol: Aim2^{Gt(CSG445)Byg}
• Allele Name: gene trap CSG445, BayGenomics
• Allele ID: MGI:3877800
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aim2^Gt(CSG445)Byg/Aim2^Gt(CSG445)Byg	B6.129P2-Aim2^Gt(CSG445)Byg/J	MGI:5789964
hm2	Aim2^Gt(CSG445)Byg/Aim2^Gt(CSG445)Byg	involves: 129P2/OlaHsd	MGI:5085874
hm3	Aim2^Gt(CSG445)Byg/Aim2^Gt(CSG445)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:4442205

Genotype
MGI:5789964

hm1

• Allelic Composition: Aim2^{Gt(CSG445)Byg}/Aim2^{Gt(CSG445)Byg}
• Genetic Background: B6.129P2-Aim2^{Gt(CSG445)Byg}/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased macrophage apoptosis ( J:234263 )

• macrophages are protected from pyroptotic cell death in response to calf thymus DNA as compared to wild type controls

hematopoietic system

decreased macrophage apoptosis ( J:234263 )

• macrophages are protected from pyroptotic cell death in response to calf thymus DNA as compared to wild type controls

immune system

decreased macrophage apoptosis ( J:234263 )

• macrophages are protected from pyroptotic cell death in response to calf thymus DNA as compared to wild type controls

abnormal interferon secretion ( J:234263 )

• production of type I interferon is enhanced in macrophages following transfection with dsDNA (calf thymus DNA)

decreased interleukin-1 beta secretion ( J:234263 )

• macrophages fail to secrete IL1B in response to calf thymus DNA as compared to wild type controls

Genotype
MGI:5085874

hm2

• Allelic Composition: Aim2^{Gt(CSG445)Byg}/Aim2^{Gt(CSG445)Byg}
• Genetic Background: involves: 129P2/OlaHsd

immune system

immune system phenotype ( J:173245 )

N • mice co-housed with wild-type mice do not affect the susceptibility to induced colitis of wild-type mice

Genotype
MGI:4442205

hm3

• Allelic Composition: Aim2^{Gt(CSG445)Byg}/Aim2^{Gt(CSG445)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

decreased NK cell number ( J:158969 )

• mCMV-treated mice exhibit reduced NK cells in the spleen and IFN-gamma producing splenic NK cells compared with similarly treated wild-type mice

abnormal macrophage physiology ( J:158969 )

• poly-dA:dT-treated macrophages exhibit less pyrotosis (inflammatory form of cell death) similarly treated wild-type cells

• however, macrophages respond normally to anthrax lethal toxin, ATP, nigericin, S. typhimurium, or Sendai virus

decreased circulating interleukin-18 level ( J:158969 )

• in mCMV-treated mice

increased interferon-beta secretion ( J:158969 )

• synthetic B-form dsDNA (poly-dA:dT)-treated splenocytes and thioglycollate-elicited macrophages produce more IFN-beta than similarly treated wild-type cells

• however, IFN-beta production by mCMV-treated macrophages is normal

decreased interleukin-1 beta secretion ( J:158969 )

• in response to a synthetic B-form dsDNA (poly-dA:dT), F. tularensis live vaccine strain, L. monocytogenes, mCMV, or Vaccinia Virus, macrophages produce less IL1b than similarly treated wild-type cells

• however, macrophages treated with HSV-1 exhibit normal IL1beta production

decreased interleukin-18 secretion ( J:158969 )

• however, macrophages treated with HSV-1 exhibit normal IL1beta production

increased susceptibility to bacterial infection ( J:158969 )

• macrophages treated with F. tularensis live vaccine strain or L. monocytogenes secrete less compared with similarly treated wild-type cells due to impaired inflammasome activation

increased susceptibility to Herpesvirales infection ( J:158969 )

• macrophages and bone marrow-derived dendritic cells treated with mCMV produce less IL1b than similarly treated wild-type cells

• mCMV-treated mice exhibit reduced serum IL18 levels, fewer NK cells in the spleen, fewer IFN-gamma-producing splenic NK cells, and increased viral titers compared with similarly treated wild-type mice

• however, macrophages treated with HSV-1 exhibit normal IL1beta production and mCMV-treated mice exhibit normal TNF and IFN-beta levels

increased susceptibility to Poxviridae infection ( J:158969 )

• macrophages and bone marrow-derived dendritic cells treated with Vaccinia virus produce less IL1b than similarly treated wild-type cells

homeostasis/metabolism

decreased circulating interleukin-18 level ( J:158969 )

• in mCMV-treated mice

hematopoietic system

decreased NK cell number ( J:158969 )

• mCMV-treated mice exhibit reduced NK cells in the spleen and IFN-gamma producing splenic NK cells compared with similarly treated wild-type mice

abnormal macrophage physiology ( J:158969 )

• poly-dA:dT-treated macrophages exhibit less pyrotosis (inflammatory form of cell death) similarly treated wild-type cells

• however, macrophages respond normally to anthrax lethal toxin, ATP, nigericin, S. typhimurium, or Sendai virus