All Phenotypes Thop1<Gt(CSG163)Byg> MGI Mouse

increased granulocyte number ( J:290567 )

• increase in the percentage of granulocytes in females

decreased lymphocyte cell number ( J:290567 )

• decrease in the percentage of lymphocytes in females

increased monocyte cell number ( J:290567 )

• increase in the percentage of monocytes in females

increased susceptibility to experimental autoimmune encephalomyelitis ( J:290567 )

• clinical scores at 17-26 days post immunization are worse than wild-type controls

• symptoms are associated with increased TNF levels in the dorsal hippocampus and spinal cord at 26 days post immunization

decreased susceptibility to infection ( J:290567 )

• following cecal ligation and puncture to induce sepsis, surviving mice show increased travel distances and average speeds compared to surviving wild-type controls

decreased susceptibility to infection induced morbidity/mortality ( J:290567 )

• following cecal ligation and puncture to induce sepsis, mortality is reduced to 30% in homozygous mice compared to 50% in wild type controls

behavior/neurological phenotype ( J:290567 )

N	• locomotor activity and rearing behavior in an open field are similar to controls and no alterations in anxiety related behavior are seen in an elevated plus maze • no alterations in performance in a Barnes maze or novel object recognition test

impaired passive avoidance behavior ( J:290567 )

• reduced latency to step down in a passive avoidance assay

abnormal depression-related behavior ( J:290567 )

• display slightly greater latency to first immobility episode and greater immobility periods on the second day of forced swim test experiments

• in a tail suspension test, mice display immobility postures that last longer than in wild-type controls

decreased thermal nociceptive threshold ( J:290567 )

• while basal latency to withdrawal is similar to wild-type controls, following intraplantar injection of bradykinin latency of withdrawal is significantly lower in homozygous mice compare to wild-type controls

abnormal nervous system physiology ( J:290567 )

• turnover ratios of 5-hydroxyindoleacetic acid/serotonin, HVA/dopamine, and 3,4-dihydroxyphenylacteic acid+homovanillic acid/dopamine are lower in the striatum compared to wild-type controls

decreased prepulse inhibition ( J:290567 )

• impaired prepulse inhibition after presentation of an 80 dB prepulse, but not after 75 or 85 dB prepulses

• treatment with clozapine restored the prepulse inhibition at 80dB and enhanced the prepulse inhibition at 85 dB

increased bleeding time ( J:290567 )

• prolonged bleeding following small surgical procedures

• however, clotting time, clotting formation time, maximum clotting firmness, and maximum lysis are all similar to controls