All Phenotypes Thop1<Gt(CSG163)Byg> MGI Mouse

increased granulocyte number ( J:290567 )

• increase in the percentage of granulocytes in females

decreased lymphocyte cell number ( J:290567 )

• decrease in the percentage of lymphocytes in females

increased monocyte cell number ( J:290567 )

• increase in the percentage of monocytes in females

increased susceptibility to experimental autoimmune encephalomyelitis ( J:290567 )

• clinical scores at 17-26 days post immunization are worse than wild-type controls

• symptoms are associated with increased TNF levels in the dorsal hippocampus and spinal cord at 26 days post immunization

decreased susceptibility to infection ( J:290567 )

• following cecal ligation and puncture to induce sepsis, surviving mice show increased travel distances and average speeds compared to surviving wild-type controls

decreased susceptibility to infection induced morbidity/mortality ( J:290567 )

• following cecal ligation and puncture to induce sepsis, mortality is reduced to 30% in homozygous mice compared to 50% in wild type controls

behavior/neurological phenotype ( J:290567 )

N	• no alterations in performance in a Barnes maze or novel object recognition test • locomotor activity and rearing behavior in an open field are similar to controls and no alterations in anxiety related behavior are seen in an elevated plus maze

impaired passive avoidance behavior ( J:290567 )

• reduced latency to step down in a passive avoidance assay

abnormal depression-related behavior ( J:290567 )

• display slightly greater latency to first immobility episode and greater immobility periods on the second day of forced swim test experiments

• in a tail suspension test, mice display immobility postures that last longer than in wild-type controls

decreased thermal nociceptive threshold ( J:290567 )

• while basal latency to withdrawal is similar to wild-type controls, following intraplantar injection of bradykinin latency of withdrawal is significantly lower in homozygous mice compare to wild-type controls

abnormal nervous system physiology ( J:290567 )

• turnover ratios of 5-hydroxyindoleacetic acid/serotonin, HVA/dopamine, and 3,4-dihydroxyphenylacteic acid+homovanillic acid/dopamine are lower in the striatum compared to wild-type controls

decreased prepulse inhibition ( J:290567 )

• impaired prepulse inhibition after presentation of an 80 dB prepulse, but not after 75 or 85 dB prepulses

• treatment with clozapine restored the prepulse inhibition at 80dB and enhanced the prepulse inhibition at 85 dB

increased bleeding time ( J:290567 )

• prolonged bleeding following small surgical procedures

• however, clotting time, clotting formation time, maximum clotting firmness, and maximum lysis are all similar to controls