Phenotypes associated with this allele

• Allele Symbol: Arfgef1^{Gt(CSH465)Byg}
• Allele Name: gene trap CSH465, BayGenomics
• Allele ID: MGI:3878593
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arfgef1^Gt(CSH465)Byg/Arfgef1^Gt(CSH465)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:6094257

Genotype
MGI:6094257

hm1

• Allelic Composition: Arfgef1^{Gt(CSH465)Byg}/Arfgef1^{Gt(CSH465)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:248338 )

• mice die within 1 day of birth

nervous system

increased neuron apoptosis ( J:248338 )

• in the neocortex at E15.5

• of postmitotic neurons in the hippocampus and neocortex at E17.5

• of deep layer neurons

• however, no apoptosis or abnormal migration is detected in interneurons

abnormal neuron differentiation ( J:248338 )

• delay in neuronal polarization in vitro

abnormal axon extension ( J:248338 )

delayed axon extension ( J:248338 )

abnormal axon guidance ( J:248338 )

• at E17.5, axon fascicles extend toward the piriform are rather than inward to form the external capsule unlike in wild-type mice

decreased brain size ( J:248338 )

• reduced length and width

• however, mice exhibit normal histological and neuronal progenitor cell numbers

enlarged lateral ventricles ( J:248338 )

abnormal corpus callosum morphology ( J:248338 )

• thinner relative to the height or width of the brain than in wild-type mice

absent anterior commissure ( J:248338 )

small hippocampus ( J:248338 )

decreased neocortex size ( J:248338 )

• small and thin

thin cerebral cortex ( J:248338 )

• at E17.5

small cerebellum ( J:248338 )

abnormal glutaminergic neuron morphology ( J:248338 )

• hypersensitivity to glutamate

behavior/neurological

absent gastric milk in neonates ( J:248338 )

cellular

increased neuron apoptosis ( J:248338 )

• in the neocortex at E15.5

• of postmitotic neurons in the hippocampus and neocortex at E17.5

• of deep layer neurons

• however, no apoptosis or abnormal migration is detected in interneurons

abnormal neuron differentiation ( J:248338 )

• delay in neuronal polarization in vitro

abnormal axon extension ( J:248338 )

delayed axon extension ( J:248338 )

abnormal axon guidance ( J:248338 )

• at E17.5, axon fascicles extend toward the piriform are rather than inward to form the external capsule unlike in wild-type mice