All Phenotypes Mcm7<Gt(YTA285)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mcm7^{Gt(YTA285)Byg}
gene trap YTA285, BayGenomics
MGI:3880493

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcm7^{Gt(YTA285)Byg}/Mcm7^{Gt(YTA285)Byg}	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838134
ht2	Mcm7^{Gt(YTA285)Byg}/Mcm7⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838136
cx3	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838124
cx4	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺	involves: 129P2/OlaHsd * C3HeB/FeJ	MGI:4838137
cx5	Mcm4^chaos3/Mcm4^chaos3 Mcm7^{Gt(YTA285)Byg}/Mcm7⁺	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J	MGI:4838117

Allelic Composition	Mcm7^{Gt(YTA285)Byg}/Mcm7^{Gt(YTA285)Byg}
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm7^{Gt(YTA285)Byg} mutation (0 available); any Mcm7 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:165667 )

• no viable mice are present at birth

Allelic Composition	Mcm7^{Gt(YTA285)Byg}/Mcm7⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm7^{Gt(YTA285)Byg} mutation (0 available); any Mcm7 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (51 available)
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)
Mcm7^{Gt(YTA285)Byg} mutation (0 available); any Mcm7 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm2^{Gt(AB0178)Wtsi}/Mcm2⁺ Mcm3^{Gt(RRR002)Byg}/Mcm3⁺ Mcm4^{Gt(RRE056)Byg}/Mcm4⁺ Mcm6^{Gt(YHD248)Byg}/Mcm6⁺ Mcm7^{Gt(YTA285)Byg}/Mcm7⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2^{Gt(AB0178)Wtsi} mutation (0 available); any Mcm2 mutation (51 available)
Mcm3^{Gt(RRR002)Byg} mutation (0 available); any Mcm3 mutation (43 available)
Mcm4^{Gt(RRE056)Byg} mutation (0 available); any Mcm4 mutation (43 available)
Mcm6^{Gt(YHD248)Byg} mutation (0 available); any Mcm6 mutation (37 available)
Mcm7^{Gt(YTA285)Byg} mutation (0 available); any Mcm7 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

Allelic Composition	Mcm4^chaos3/Mcm4^chaos3 Mcm7^{Gt(YTA285)Byg}/Mcm7⁺
Genetic Background	involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm4^chaos3 mutation (1 available); any Mcm4 mutation (43 available)
Mcm7^{Gt(YTA285)Byg} mutation (0 available); any Mcm7 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:165667 )

• only 8% of expected mice survive to weaning

prenatal lethality, incomplete penetrance ( J:165667 )

• 50% of expected mice are liveborn

hematopoietic system

abnormal erythrocyte morphology ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4^chaos3 homozygotes

reticulocytosis ( J:165667 )

• mice exhibit an increase in the number of CD71+ (proliferating cells, reticulocytes, erythroid precursors) cells compared with Mcm4^chaos3 homozygotes

cellular

chromosomal instability ( J:165667 )

• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4^chaos3 homozygotes

growth/size/body

decreased body weight ( J:165667 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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