Phenotypes associated with this allele

• Allele Symbol: Srebf2^{Gt(YTA054)Byg}
• Allele Name: gene trap YTA054, BayGenomics
• Allele ID: MGI:3880672
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Srebf2^Gt(YTA054)Byg/Srebf2^Gt(YTA054)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:5293676
ht2	Srebf2^Gt(YTA054)Byg/Srebf2^lop13	involves: 129P2/OlaHsd * 129T1/Sv * C57BL/6J	MGI:5293677

Genotype
MGI:5293676

hm1

• Allelic Composition: Srebf2^{Gt(YTA054)Byg}/Srebf2^{Gt(YTA054)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:176249 )

• no homozygotes are detected at P0.5

Genotype
MGI:5293677

ht2

• Allelic Composition: Srebf2^{Gt(YTA054)Byg}/Srebf2^lop13
• Genetic Background: involves: 129P2/OlaHsd * 129T1/Sv * C57BL/6J

Lens abnormalities in Srebf2^{Gt(YTA054)Byg}/Srebf2^lop13 eyes

mortality/aging

prenatal lethality, incomplete penetrance ( J:176249 )

• deviation from expected numbers suggests some embryonic lethality

vision/eye

abnormal lens fiber morphology ( J:176249 )

• abnormalities of the lens fiber cells, such as swollen cortical fibers and bladder cells, are seen

• degeneration of lens fibers is seen

cataract ( J:176249 )

• at 6 weeks of age

integument

abnormal skin condition ( J:176249 )

• develop persistent wounds of the skin in areas around the eye and on the back of the neck