Phenotypes associated with this allele

• Allele Symbol: Dapk3^{Gt(YTA407)Byg}
• Allele Name: gene trap YTA407, BayGenomics
• Allele ID: MGI:3882715
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dapk3^Gt(YTA407)Byg/Dapk3^Gt(YTA407)Byg	either: B6.129P2-Dapk3^Gt(YTA407)Byg or (involves: 129P2/OlaHsd * C57BL/6)	MGI:5660505
ht2	Dapk3^Gt(YTA407)Byg/Dapk3^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5640955

Genotype
MGI:5660505

hm1

• Allelic Composition: Dapk3^{Gt(YTA407)Byg}/Dapk3^{Gt(YTA407)Byg}
• Genetic Background: either: B6.129P2-Dapk3^{Gt(YTA407)Byg} or (involves: 129P2/OlaHsd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:219673 )

• no homozygotes are identified at E12.5, E10.5, or E8.5 on a mixed or backcrossed C57BL/6 (N5) background

• homozygous blastocysts are isolated at E3.5, indicating that lethality is likely occurring post-implantation

• normal distribution of homozygous embryos across blastocyst, morula, and premorula stages

embryo

abnormal embryo development ( J:219673 )

• mutant blastocysts are able to implant, but subsequent development is impaired

Genotype
MGI:5640955

ht2

• Allelic Composition: Dapk3^{Gt(YTA407)Byg}/Dapk3⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:219673 )

• heterozygotes appear to develop and grow normally with no overt phenotypes under standard laboratory conditions