Analysis Tools
mortality/aging
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• half of expected mice die prior to birth
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reproductive system
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• mice are infertile when crossed to each other
• however, mice fertile when mated to wild-type mice
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hematopoietic system
| N |
• mice exhibit normal numbers of platelets
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small thymus
(
J:174870
)
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• megakaryocyte-erythroid progenitors and erythroblasts are slightly decreased compared to in wild-type
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• old mice exhibit decreased common myeloid progenitors (CMPs) and granulocyte macrophage progenitors (GMPs) compared with wild-type mice
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• young mice exhibit decreased common lymphocyte progenitor cells compared with wild-type mice
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• in young and old mice
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• circulating in old mice
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• in the thymus
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• in the thymus
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• in the thymus
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• in the thymus
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• in the spleen
• 2.5- to 5-fold in the blood of old mice
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• in old mice
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• in young and old mice
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• in young and old mice
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• in the thymus
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• in the thymus
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• mice exhibit reduced numbers of primitive hematopoietic, intermediate progenitors, lymphoid myeloid primed multipotent progenitors (LMPPs; in young and old mice), and short term hematopoietic stem cells (in old mice) compared with wild-type mice
• however, mice exhibit normal numbers of long term hematopoietic stem cells
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• young and old mice exhibit decreased myeloid lineage cells compared with wild-type mice
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• in the spleen
• in the bone marrow of young and old mice
• 2-fold in the blood of old mice
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• in the spleen
• in the bone marrow of old mice
• 2-fold in the blood of old mice
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small spleen
(
J:174870
)
|
• hematopoietic stem cells exhibit a slight decreased in cells in the S-G2/M phase compared with wild-type cells
• in bone marrow transplantation assays, hematopoietic stem cells exhibit reduced repopulation capacity compared with wild-type cells
• however, apoptosis rates are not significantly different
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growth/size/body
immune system
small thymus
(
J:174870
)
|
• circulating in old mice
|
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• in the thymus
|
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• in the thymus
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• in the thymus
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• in the thymus
|
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• in the spleen
• 2.5- to 5-fold in the blood of old mice
|
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• in old mice
|
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• in young and old mice
|
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• in young and old mice
|
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• in the thymus
|
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• in the thymus
|
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• young and old mice exhibit decreased myeloid lineage cells compared with wild-type mice
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• in the spleen
• in the bone marrow of young and old mice
• 2-fold in the blood of old mice
|
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• in the spleen
• in the bone marrow of old mice
• 2-fold in the blood of old mice
|
small spleen
(
J:174870
)
endocrine/exocrine glands
small thymus
(
J:174870
)
|
• in the thymus
|
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• in the thymus
|
