Phenotypes associated with this allele

• Allele Symbol: Atad3a^{Gt(E118D03)Wrst}
• Allele Name: gene trap E118D03, German Gene Trap Consortium
• Allele ID: MGI:3896084
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atad3a^Gt(E118D03)Wrst/Atad3a^Gt(E118D03)Wrst	involves: 129P2/OlaHsd * C57BL/6J	MGI:5487683

Genotype
MGI:5487683

hm1

• Allelic Composition: Atad3a^{Gt(E118D03)Wrst}/Atad3a^{Gt(E118D03)Wrst}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:195793 )

• die between E7.5 and E8.5

embryo

abnormal embryo development ( J:195793 )

• embryos have an oval to conic shape resulting from a failure to extend the proximo-distal axis

abnormal developmental patterning ( J:195793 )

abnormal ectoderm development ( J:195793 )

• embryonic ectoderm appears less differentiated at E7.5 and embryos lack a proamniotic canal

abnormal endoderm development ( J:195793 )

• embryonic endoderm appears less differentiated at E7.5

failure to gastrulate ( J:195793 )

• at E7.5 internal cavitation is completely absent

abnormal proximal-distal axis patterning ( J:195793 )

• a failure to extend the proximo-distal axis is detected at E6.5

embryonic growth retardation ( J:195793 )

• at the egg cylinder stage (E6.5) embryos show a total growth reduction

• at the gastrula stage (E7.5) embryos resemble wild-type embryos at E5.5

small embryonic epiblast ( J:195793 )

• even after 3 days of culture of embryos collected at E6.5

abnormal trophectoderm morphology ( J:195793 )

• minimal outgrowth in cultured E6.5 embryos even after 3 - 4 days in culture

• apparent defect in the ability of trophoblast stem cells or their very early descendents to differentiate into later trophoblast cell types or trophoblast giant cells and the

• maintenance of trophoblast stem cells is impaired

abnormal ectoplacental cone morphology ( J:195793 )

• strongly reduced or absent at E7.5

absent ectoplacental cone ( J:195793 )

• at E6.5

abnormal extraembryonic ectoderm morphology ( J:195793 )

• strongly reduced or absent at E7.5

absent extraembryonic ectoderm ( J:195793 )

• at E7.5

growth/size/body

embryonic growth retardation ( J:195793 )

• at the egg cylinder stage (E6.5) embryos show a total growth reduction

• at the gastrula stage (E7.5) embryos resemble wild-type embryos at E5.5