Phenotypes associated with this allele

• Allele Symbol: Tbc1d1^{Gt(E140H06)Wrst}
• Allele Name: gene trap E140H06, German Gene Trap Consortium
• Allele ID: MGI:3896754
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbc1d1^Gt(E140H06)Wrst/Tbc1d1^Gt(E140H06)Wrst	B6.129P2-Tbc1d1^Gt(E140H06)Wrst	MGI:5543790

Genotype
MGI:5543790

hm1

• Allelic Composition: Tbc1d1^{Gt(E140H06)Wrst}/Tbc1d1^{Gt(E140H06)Wrst}
• Genetic Background: B6.129P2-Tbc1d1^{Gt(E140H06)Wrst}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:203285 )

♂N • male mice fed a high-fat diet exhibit normal glucose tolerance and insulin sensitivity

abnormal homeostasis ( J:203285 )

♂ • reduced whole-body carbohydrate oxidation rates in male mice fed a high-fat diet during the light and dark phase

abnormal lipid oxidation ( J:203285 )

♂ • increased whole-body fat oxidation in male mice fed a high-fat diet during the light and dark phase

increased fatty acid oxidation ( J:203285 )

♂ • enhanced fatty acid oxidation in AICAR-stimulated muscle cells from male mice fed standard chow

decreased susceptibility to diet-induced obesity ( J:203285 )

♂ • at 15 weeks when fed a high fat diet

decreased respiratory quotient ( J:203285 )

♂ • in male mice fed a high-fat diet, but not standard chow, in both the light and dark phase

increased basal metabolism ( J:203285 )

♂ • male mice fed a high-fat diet exhibit increased resting metabolic rate compared with wild-type mice

♂ • however, 24 hr energy expenditure is normal

growth/size/body

decreased lean body mass ( J:203285 )

♂ • in male mice fed standard chow or a high-fat diet

decreased body weight ( J:203285 )

♂ • when fed standard chow or a high-fat diet

decreased susceptibility to diet-induced obesity ( J:203285 )

♂ • at 15 weeks when fed a high fat diet

adipose tissue

decreased total body fat amount ( J:203285 )

♂ • in male mice fed a high-fat diet, but not standard chow

muscle

abnormal muscle cell glucose uptake ( J:203285 )

♂ • in insulin- or AICAR-stimulated muscle cells from male mice fed standard chow or a high-fat diet

♂ • however, basal uptake is normal

cellular

abnormal muscle cell glucose uptake ( J:203285 )

♂ • in insulin- or AICAR-stimulated muscle cells from male mice fed standard chow or a high-fat diet

♂ • however, basal uptake is normal

abnormal lipid oxidation ( J:203285 )

♂ • increased whole-body fat oxidation in male mice fed a high-fat diet during the light and dark phase

increased fatty acid oxidation ( J:203285 )

♂ • enhanced fatty acid oxidation in AICAR-stimulated muscle cells from male mice fed standard chow