Phenotypes associated with this allele

• Allele Symbol: Chd1l^{Gt(E305F08)Wrst}
• Allele Name: gene trap E305F08, German Gene Trap Consortium
• Allele ID: MGI:3910467
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chd1l^Gt(E305F08)Wrst/Chd1l^Gt(E305F08)Wrst	involves: 129 * 129P2/OlaHsd	MGI:6511229

Genotype
MGI:6511229

hm1

• Allelic Composition: Chd1l^{Gt(E305F08)Wrst}/Chd1l^{Gt(E305F08)Wrst}
• Genetic Background: involves: 129 * 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:302849 )

• mice are born at slightly reduced sub-Mendelian ratios of 14% versus the expected 25%

• however, mice have a normal lifespan

growth/size/body

decreased body size ( J:302849 )

• mice are smaller throughout adulthood

decreased body weight ( J:302849 )

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:302849 )

• mice treated with the carcinogen diethylnitrosamine (DEN) at 2 weeks of age develop smaller liver tumors than wild-type mice and show a moderate decrease in the number of hepatocellular adenomas that form, indicating that mice are less susceptible to development of epithelial liver tumors

increased physiological sensitivity to xenobiotic ( J:302849 )

• mouse embryonic fibroblasts (MEFs) show increased sensitivity to PARPi, with reduced MEF survival after treatment with Olaparib

• MEFs show increased sensitivity to the alkylating agent methyl-methanesulfonate, with reduced MEF survival after treatment

neoplasm

decreased tumor incidence ( J:302849 )

• mice exhibit a tendency to develop fewer spontaneous epithelial or mesenchymal tumors, with only 37% of mice developing epithelial-mesenchymal tumors compared to 57% of wild-type mice

• mice show a mild decrease in the number of mice developing one or more tumor and mice do not develop mesenchymal tumors

• epithelial tumor-free survival tends to be slightly increased, with a median survival of 741 days compared to 695 for wild-type mice

decreased incidence of tumors by chemical induction ( J:302849 )

• mice treated with the carcinogen diethylnitrosamine (DEN) at 2 weeks of age develop smaller liver tumors than wild-type mice and show a moderate decrease in the number of hepatocellular adenomas that form, indicating that mice are less susceptible to development of epithelial liver tumors