Phenotypes associated with this allele

• Allele Symbol: 2500002B13Rik^{Gt(Ayu21-T167)Imeg}
• Allele Name: gene trap Ayu21-T167, Institute of Molecular Embryology and Genetics
• Allele ID: MGI:3923455
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	2500002B13Rik^Gt(Ayu21-T167)Imeg/2500002B13Rik^Gt(Ayu21-T167)Imeg	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:6782389

Genotype
MGI:6782389

hm1

• Allelic Composition: 2500002B13Rik^{Gt(Ayu21-T167)Imeg}/2500002B13Rik^{Gt(Ayu21-T167)Imeg}
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber physiology ( J:311513 )

• decrease in basal, state 3 and state 3u respiration in heart mitochondria

• levels of respiratory chain complex I are significantly increased but the activity of complex I is significantly decreased in hearts compared to wild-type controls

increased response of heart to induced stress ( J:311513 )

• following transverse aorta constriction mice develop marked left ventricular dilatation with a significant decrease in fractional shortening resulting in heart failure compared to wild-type controls that develop adaptive cardiac hypertrophy with moderate left ventricular dilation

• cardiomyocyte enlargement following transverse aorta constriction is more severe than in controls

• more than 70% of mice die by 140 days post transverse aorta constriction compared to only 20% of controls

cellular

abnormal mitochondrial physiology ( J:311513 )

• decrease in basal, state 3 and state 3u respiration in heart mitochondria

• levels of respiratory chain complex I are significantly increased but the activity of complex I is significantly decreased in hearts compared to wild-type controls

homeostasis/metabolism

increased response of heart to induced stress ( J:311513 )

• following transverse aorta constriction mice develop marked left ventricular dilatation with a significant decrease in fractional shortening resulting in heart failure compared to wild-type controls that develop adaptive cardiac hypertrophy with moderate left ventricular dilation

• cardiomyocyte enlargement following transverse aorta constriction is more severe than in controls

• more than 70% of mice die by 140 days post transverse aorta constriction compared to only 20% of controls