Analysis Tools|
Allele Symbol Allele Name Allele ID |
Sppl2bGt(Ayu21-T160)Imeg gene trap Ayu21-T160, Institute of Molecular Embryology and Genetics MGI:3923485 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• viable with no overt impairments
• B cell maturation and function are normal
• basal immunoglobulin concentrations in plasma are normal
• no reduction in CD11c+ MHC-II+ cells
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• significant reduction of total B cells in the spleen, lymph nodes, and peritoneal cavity
• B cell numbers similar to mice homozygous only for Sppl2atm1Basc
|
|
• numerous endosomal vesicles as is seen in mice homozygous only for Sppl2atm1Basc
|
|
• levels decreased to near limit of detectability as seen in mice homozygous only for Sppl2atm1Basc
|
|
• significant reduction of total B cells in the spleen, lymph nodes, and peritoneal cavity
• B cell numbers similar to mice homozygous only for Sppl2atm1Basc
|
|
• numerous endosomal vesicles as is seen in mice homozygous only for Sppl2atm1Basc
|
|
• levels decreased to near limit of detectability as seen in mice homozygous only for Sppl2atm1Basc
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/05/2024 MGI 6.24 |
|
|
|
||
