Analysis Tools|
Allele Symbol Allele Name Allele ID |
Sppl2bGt(Ayu21-T160)Imeg gene trap Ayu21-T160, Institute of Molecular Embryology and Genetics MGI:3923485 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• viable with no overt impairments
• B cell maturation and function are normal
• basal immunoglobulin concentrations in plasma are normal
• no reduction in CD11c+ MHC-II+ cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• significant reduction of total B cells in the spleen, lymph nodes, and peritoneal cavity
• B cell numbers similar to mice homozygous only for Sppl2atm1Basc
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• numerous endosomal vesicles as is seen in mice homozygous only for Sppl2atm1Basc
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• levels decreased to near limit of detectability as seen in mice homozygous only for Sppl2atm1Basc
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• significant reduction of total B cells in the spleen, lymph nodes, and peritoneal cavity
• B cell numbers similar to mice homozygous only for Sppl2atm1Basc
|
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• numerous endosomal vesicles as is seen in mice homozygous only for Sppl2atm1Basc
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• levels decreased to near limit of detectability as seen in mice homozygous only for Sppl2atm1Basc
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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