Phenotypes associated with this allele

• Allele Symbol: Cadm1^{Gt(Ayu21-W34)Imeg}
• Allele Name: gene trap Ayu21-W34, Institute of Molecular Embryology and Genetics
• Allele ID: MGI:3923695
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cadm1^Gt(Ayu21-W34)Imeg/Cadm1^Gt(Ayu21-W34)Imeg	involves: C57BL/6 * CBA/JNCrlj	MGI:5306626

Genotype
MGI:5306626

hm1

• Allelic Composition: Cadm1^{Gt(Ayu21-W34)Imeg}/Cadm1^{Gt(Ayu21-W34)Imeg}
• Genetic Background: involves: C57BL/6 * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:178612 )

• impaired after stimulation with anti-mCD3/28

abnormal T cell differentiation ( J:178612 )

• substantially blocked at the double positive stage

abnormal T cell receptor V(D)J recombination ( J:178612 )

• TCR beta chain gene rearrangement is impaired

increased double-positive T cell number ( J:178612 )

• in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:178612 )

• in the thymus, spleen, and lymph node

decreased CD8-positive, alpha-beta T cell number ( J:178612 )

• in the thymus, spleen, and lymph node

decreased interferon-gamma secretion ( J:178612 )

• in CD8+ T cells stimulated with anti-mCD3/28

• however, response to PMA/A23187 is normal

decreased interleukin-2 secretion ( J:178612 )

• in thymocytes and CD4+T cells stimulated with anti-mCD3/28

• however, CD4+ T cells response to PMA/A23187 is normal

decreased interleukin-4 secretion ( J:178612 )

• in CD4+ T cells stimulated with anti-mCD3/28

• however, response to PMA/A23187 is normal

growth/size/body

decreased body size ( J:178612 )

• at 4 weeks of age

decreased body weight ( J:178612 )

• at 4 to 8 weeks of age

decreased fetal size ( J:178612 )

• at E18.5

hematopoietic system

decreased T cell proliferation ( J:178612 )

• impaired after stimulation with anti-mCD3/28

abnormal T cell differentiation ( J:178612 )

• substantially blocked at the double positive stage

abnormal T cell receptor V(D)J recombination ( J:178612 )

• TCR beta chain gene rearrangement is impaired

increased double-positive T cell number ( J:178612 )

• in the thymus

decreased CD4-positive, alpha-beta T cell number ( J:178612 )

• in the thymus, spleen, and lymph node

decreased CD8-positive, alpha-beta T cell number ( J:178612 )

• in the thymus, spleen, and lymph node

cellular

decreased T cell proliferation ( J:178612 )

• impaired after stimulation with anti-mCD3/28