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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nrbf2Gt(Ayu21-W143)Imeg
gene trap Ayu21-W143, Institute of Molecular Embryology and Genetics
MGI:3923820
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nrbf2Gt(Ayu21-W143)Imeg/Nrbf2Gt(Ayu21-W143)Imeg involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:6380656


Genotype
MGI:6380656
hm1
Allelic
Composition
Nrbf2Gt(Ayu21-W143)Imeg/Nrbf2Gt(Ayu21-W143)Imeg
Genetic
Background
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrbf2Gt(Ayu21-W143)Imeg mutation (0 available); any Nrbf2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• livers exhibit sporadic apoptosis of hepatocytes
• mice exhibit focal ductular reaction indicative of liver injury by 10 months of age
• mice develop focal liver necrosis by 10 months of age

homeostasis/metabolism
• MEFs show a decrease of autophagosome numbers under normal conditions and rapamycin treatment to induced autophagy
• MEFs also show a decrease in phagophores, the autophagosome precursors under normal condition, rapamycin treatment, and nutrient withdrawal
• marker analysis indicates impaired autophagosome maturation, particularly under autophagy induction
• mice show partially impaired autophagy in livers

cellular
• MEFs show a decrease of autophagosome numbers under normal conditions and rapamycin treatment to induced autophagy
• MEFs also show a decrease in phagophores, the autophagosome precursors under normal condition, rapamycin treatment, and nutrient withdrawal
• marker analysis indicates impaired autophagosome maturation, particularly under autophagy induction
• mice show partially impaired autophagy in livers
• MEFs are more susceptible to ER stress induced by thapsigargin or tunicamycin, with cells showing impaired autophagy activation and an increase in morphology changes and cell death
• livers exhibit sporadic apoptosis of hepatocytes

mortality/aging
N
• mice show no enhanced mortality compared to wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory