Phenotypes associated with this allele

• Allele Symbol: Suclg2^{Gt(Ayu21-KBW131)Imeg}
• Allele Name: gene trap Ayu21-KBW131, Institute of Molecular Embryology and Genetics
• Allele ID: MGI:3923833
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Suclg2^Gt(Ayu21-KBW131)Imeg/Suclg2^Gt(Ayu21-KBW131)Imeg	involves: C57BL/6 * C57BL/6N	MGI:6153992
ht2	Suclg2^Gt(Ayu21-KBW131)Imeg/Suclg2^+	involves: C57BL/6 * C57BL/6N	MGI:6153994
cx3	Sucla2^Gt(IST10208H1)Tigm/Sucla2^+ Suclg2^Gt(Ayu21-KBW131)Imeg/Suclg2^+	involves: 129S/SvEv * C57BL/6 * C57BL/6N	MGI:6153997

Genotype
MGI:6153992

hm1

• Allelic Composition: Suclg2^{Gt(Ayu21-KBW131)Imeg}/Suclg2^{Gt(Ayu21-KBW131)Imeg}
• Genetic Background: involves: C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:241325 )

• no pups are born

Genotype
MGI:6153994

ht2

• Allelic Composition: Suclg2^{Gt(Ayu21-KBW131)Imeg}/Suclg2⁺
• Genetic Background: involves: C57BL/6 * C57BL/6N

cellular

abnormal mitochondrial physiology ( J:241325 )

• some reduced state 3 respiration in mitochondria from 6-months old mice and state 2 and state 3 respiration in mitochondria from 12-months old mice

Genotype
MGI:6153997

cx3

• Allelic Composition: Sucla2^{Gt(IST10208H1)Tigm}/Sucla2⁺; Suclg2^{Gt(Ayu21-KBW131)Imeg}/Suclg2⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

cellular

decreased mitochondrial DNA content ( J:241325 )

• in mitochondria from liver and brain of 12-months old mice

decreased hepatocyte mitochondrial DNA content ( J:241325 )

abnormal oxidative phosphorylation ( J:241325 )

• significant decrease in ATP-generating activity in mitochondria from heart and brain of 12-months old mice

• significant increase in succinate dehydrogenase (electron transport chain) activity in mitochondria from heart of 12-months old mice

• ATP-generating activity in mitochondria from liver of 12-months old mice

• GTP-generating activity in mitochondria from liver, heart and brain of 12-months old mice

liver/biliary system

decreased hepatocyte mitochondrial DNA content ( J:241325 )

homeostasis/metabolism

increased circulating carnitine level ( J:241325 )

• increased levels of some carnitine esters in blood