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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prss8Gt(IST10122F12)Tigm
gene trap IST10122F12, Texas A&M Institute for Genomic Medicine
MGI:3930527
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prss8Gt(IST10122F12)Tigm/Prss8Gt(IST10122F12)Tigm involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N MGI:5440261
ht2
 		Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N MGI:5588585


Genotype
MGI:5440261
hm1
Allelic
Composition		 Prss8Gt(IST10122F12)Tigm/Prss8Gt(IST10122F12)Tigm
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8Gt(IST10122F12)Tigm mutation (0 available); any Prss8 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:188121 )
• mice die within 48 hours after birth

homeostasis/metabolism
dehydration ( J:188121 )
• mice dehydrate at a rapid pace, indicating increase in transepidermal water loss
impaired skin barrier function ( J:188121 )
• mice dehydrate at a rapid pace, indicating increase in transepidermal water loss

integument
impaired skin barrier function ( J:188121 )
• mice dehydrate at a rapid pace, indicating increase in transepidermal water loss
abnormal epidermis stratum corneum morphology ( J:188121 )
• stratum corneum is completely compacted, presenting with few intercorneocyte lacunae
• 18% reduction in the thickness of the stratum corneum




Genotype
MGI:5588585
ht2
Allelic
Composition		 Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss8Gt(IST10122F12)Tigm mutation (0 available); any Prss8 mutation (24 available)
Prss8tm1.1Bug mutation (0 available); any Prss8 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:214122 )
• 73% of mice survive the preweaning period
postnatal lethality, incomplete penetrance ( J:214122 )
• mice are born at the expected ratios and 73% survive the preweaning period

homeostasis/metabolism
impaired skin barrier function ( J:214122 )
• transepidermal water loss is marginally increased relative to wild-type mice

integument
impaired skin barrier function ( J:214122 )
• transepidermal water loss is marginally increased relative to wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory