Analysis Tools
mortality/aging
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• at E9.5 some embryos show signs of resorption and by E10.5 all embryos are in resorption
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embryo
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• contain large blood sinusoids instead of the normal vascular trees
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• most embryos are unturned at E9.5
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• anterior ectoderm is expanded and disorganized, especially towards the midline
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• the amount of mesodermal tissues seems decreased compared to wild-type controls
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• posterior axis truncation at E8.0
• complete absence of the posterior parts of the embryo at E8.5
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• severe growth retardation at E9.5
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• fails to fold properly at E8.0 and E8.5
• unfolded at E9.5
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• abnormally expanded and improperly folded neural plate at E8.0
• at E8.5 the plate fails to fold properly but continues to expand in the anterior part of the embryo
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• at E8.0 and E8.5
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• severe vascular remodeling defects at E8.75
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cardiovascular system
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• absence of intersomitic vasculature
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• absence of intersomitic vasculature
• at E8.5 no vessels are detected on the dorsal side of the head
• by E9.5 disorganized vascular networks are present on the dorsal side of the head in some embryos
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• absence of the dorsal aorta
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• contain large blood sinusoids instead of the normal vascular trees
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• at E9.5 the cardiogenic plates are unfused
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• absence of heart rudiments at E8.0 and E8.5
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• at E9.5 the cardiogenic plates are still unfused
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nervous system
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• abnormally expanded and improperly folded neural plate at E8.0
• at E8.5 the plate fails to fold properly but continues to expand in the anterior part of the embryo
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growth/size/body
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• severe growth retardation at E9.5
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