Analysis Tools
cardiovascular system
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• at 4 weeks after partial transverse aortic constriction (TAC), cross-sectional area of cardiomyocytes is significantly larger than that in wild-type controls
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• at 4 weeks after partial TAC, heart is significantly larger than in wild-type controls
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• at 4 weeks after partial TAC, mice show increased ratios of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL) relative to wild-type controls
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• at 4 weeks after partial TAC, mice exhibit exacerbated cardiac hypertrophy and significantly increased mRNA expression levels of hypertrophy markers (ANP, BNP and MYH7) relative to wild-type controls
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• at 4 weeks after partial TAC, hearts exhibit more prominent interstitial and perivascular fibrosis with significantly increased left ventricular collagen volume and mRNA expression levels of fibrosis markers relative to wild-type hearts
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• at 4 weeks after partial TAC, cardiac interstitial fibrosis is more prominent than in wild-type hearts
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• at 4 weeks after partial TAC, fractional shortening % (FS%) is significantly lower than that in wild-type controls
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• at 4 weeks after partial TAC, ejection fraction % (EF%) is significantly lower than that in wild-type controls
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• at 4 weeks after partial TAC, mice exhibit increased cardiac hypertrophy (increased ratios of heart weight to body weight, lung weight to body weight and heart weight to tibia length, larger gross heart size and cross-sectional area of cardiomyocytes) and increased cardiac fibrosis and left ventricular end-diastolic and end-systolic diameter with decreased fractional shortening and ejection fraction relative to wild-type controls
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growth/size/body
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• at 4 weeks after partial TAC, heart is significantly larger than in wild-type controls
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• at 4 weeks after partial TAC, mice show increased ratios of heart weight to body weight (HW/BW) and heart weight to tibia length (HW/TL) relative to wild-type controls
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• at 4 weeks after partial TAC, mice exhibit exacerbated cardiac hypertrophy and significantly increased mRNA expression levels of hypertrophy markers (ANP, BNP and MYH7) relative to wild-type controls
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• at 4 weeks after partial TAC, lung weight to body weight (LW/BW) ratio is higher than that in wild-type controls
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homeostasis/metabolism
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• at 4 weeks after partial TAC, mice exhibit increased cardiac hypertrophy (increased ratios of heart weight to body weight, lung weight to body weight and heart weight to tibia length, larger gross heart size and cross-sectional area of cardiomyocytes) and increased cardiac fibrosis and left ventricular end-diastolic and end-systolic diameter with decreased fractional shortening and ejection fraction relative to wild-type controls
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muscle
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• at 4 weeks after partial transverse aortic constriction (TAC), cross-sectional area of cardiomyocytes is significantly larger than that in wild-type controls
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• at 4 weeks after partial TAC, fractional shortening % (FS%) is significantly lower than that in wild-type controls
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• at 4 weeks after partial TAC, ejection fraction % (EF%) is significantly lower than that in wild-type controls
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respiratory system
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• at 4 weeks after partial TAC, lung weight to body weight (LW/BW) ratio is higher than that in wild-type controls
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cellular
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• at 4 weeks after partial TAC, cardiac interstitial fibrosis is more prominent than in wild-type hearts
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