Phenotypes associated with this allele

• Allele Symbol: Rfx2^{Gt(IST10638H11)Tigm}
• Allele Name: gene trap IST10638H11, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:3966900
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rfx2^Gt(IST10638H11)Tigm/Rfx2^Gt(IST10638H11)Tigm	either: C57BL/6N-Rfx2^Gt(IST10638H11)Tigm or (involves: C57BL/6N * CD-1)	MGI:5705076

Genotype
MGI:5705076

hm1

• Allelic Composition: Rfx2^{Gt(IST10638H11)Tigm}/Rfx2^{Gt(IST10638H11)Tigm}
• Genetic Background: either: C57BL/6N-Rfx2^{Gt(IST10638H11)Tigm} or (involves: C57BL/6N * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

In Rfx2^{Gt(IST10638H11)Tigm}/Rfx2^{Gt(IST10638H11)Tigm} testis, elongating spermatids are replaced by symblasts of spermatids

cellular

abnormal spermatid morphology ( J:227136 )

♂ • elongating spermatids are replaced by symplasts of spermatids

♂ • an accumulation of abnormal symplasts of round spermatids is observed

multinucleated giant male germ cells ( J:227136 )

♂ • an accumulation of abnormal symplasts of round spermatids is observed

reproductive system

multinucleated giant male germ cells ( J:227136 )

♂ • an accumulation of abnormal symplasts of round spermatids is observed

Leydig cell hypertrophy ( J:227136 )

♂ • Leydig cells appear enlarged

increased Leydig cell number ( J:227136 )

♂ • increased numbers of Leydig cells are present in the interstitial space

abnormal spermatogenesis ( J:227136 )

♂ • no sperm is recovered from the caudal epididymis at 12 weeks of age

♂ • no spermatozoa are present in the lumen of seminiferous tubules

♂ • however, spermatogonial cells and spermatocytes are present in mutant testes and do not appear obviously abnormal

abnormal spermatid morphology ( J:227136 )

♂ • elongating spermatids are replaced by symplasts of spermatids

♂ • an accumulation of abnormal symplasts of round spermatids is observed

abnormal spermiogenesis ( J:227136 )

♂ • differentiation of spermatids is abnormal before or at the round and elongating spermatid stage

male infertility ( J:227136 )

♂ • male homozygotes are infertile despite normal mating and plugging behavior

♂ • in contrast, female homozygotes are fertile

endocrine/exocrine glands

Leydig cell hypertrophy ( J:227136 )

♂ • Leydig cells appear enlarged

increased Leydig cell number ( J:227136 )

♂ • increased numbers of Leydig cells are present in the interstitial space

embryo

embryo phenotype ( J:227136 )

N • homozygotes appear morphologically normal at E10.5

N • no defects in neural tube closure or in organ situs (left-right patterning) are observed

behavior/neurological

behavior/neurological phenotype ( J:227136 )

N • adult homozygotes are viable, morphologically normal, and do not exhibit any obvious behavioral abnormalities