Phenotypes associated with this allele

• Allele Symbol: Irf2bp2^{Gt(IST11591C1)Tigm}
• Allele Name: gene trap IST11591C1, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:4015249
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irf2bp2^Gt(IST11591C1)Tigm/Irf2bp2^Gt(IST11591C1)Tigm	involves: C57BL/6 * C57BL/6N * FVB/N	MGI:5706994

Genotype
MGI:5706994

hm1

• Allelic Composition: Irf2bp2^{Gt(IST11591C1)Tigm}/Irf2bp2^{Gt(IST11591C1)Tigm}
• Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:228010 )

• homozygous mice are rarely obtained and do not survive past 4 weeks of age

perinatal lethality, incomplete penetrance ( J:228010 )

• embryos appear to develop normally up to E18.5 and are obtained at the expected Mendelian ratio, however live births are very rare (less than 5% of the expected number)

growth/size/body

postnatal growth retardation ( J:228010 )

• severe growth retardation

embryo

abnormal embryonic erythropoiesis ( J:228010 )

• fetal liver erythropoiesis at E11.5 and E12.5 shows altered proportions of the different developing erythroid populations, in particular within the mature Ter119+ compartment

• fetal livers show a modest decrease in proerythroblast abundance and an increase in presence of small terminally differentiated red cells

• early enucleating cells are more abundantly present in fetal livers while percentage of small and enucleated erythrocytes is reduced indicating a partial differentiation block at the erythroblast stage, before enucleation

hematopoietic system

abnormal embryonic erythropoiesis ( J:228010 )

• fetal liver erythropoiesis at E11.5 and E12.5 shows altered proportions of the different developing erythroid populations, in particular within the mature Ter119+ compartment

• fetal livers show a modest decrease in proerythroblast abundance and an increase in presence of small terminally differentiated red cells

• early enucleating cells are more abundantly present in fetal livers while percentage of small and enucleated erythrocytes is reduced indicating a partial differentiation block at the erythroblast stage, before enucleation

decreased erythroid progenitor cell number ( J:228010 )

• reduction in the double-negative immature progenitor compartment

abnormal proerythroblast morphology ( J:228010 )

• fetal livers show a modest decreased in proerythroblast abundance

increased erythroblast number ( J:228010 )

• increase in the numbers of cells in the more mature erythroblast stages (CD71+Ter119-)

decreased erythrocyte cell number ( J:228010 )

• reduction in the relative number of mature Ter119+CD71- erythrocytes

liver/biliary system

abnormal liver morphology ( J:228010 )

• fetal livers show reduced total cellularity