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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rps27lGt(IST11658B7)Tigm
gene trap IST11658B7, Texas A&M Institute for Genomic Medicine
MGI:4022789
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm C57BL/6-Rps27lGt(IST11658B7)Tigm MGI:5707898
hm2
 		Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm involves: 129 * C57BL/6N MGI:5707899
hm3
 		Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm involves: 129S2/SvPas * C57BL/6N MGI:5707902
cx4
 		Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * C57BL/6N MGI:5707900
cx5
 		Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Trp53tm1Tyj/Trp53+ 		involves: 129S2/SvPas * C57BL/6N MGI:5707901


Genotype
MGI:5707898
hm1
Allelic
Composition		 Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic
Background		 C57BL/6-Rps27lGt(IST11658B7)Tigm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps27lGt(IST11658B7)Tigm mutation (1 available); any Rps27l mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:223276 )
• Background Sensitivity: mice on a pure C57BL/6 background die within 12 days of birth while mice on a mixed 129 and C57BL/6 background exhibit 50% lethality at P18 and have a lifespan up to 35 days

hematopoietic system
increased thymocyte apoptosis ( J:223276 )
• thymocytes in the cortical and cortical-medullary junction are apoptotic and accumulate small irregular nuclear fragments
decreased thymus weight ( J:223276 )
• at P8 to P10
decreased common myeloid progenitor cell number ( J:223276 )
• due to increased apoptosis without reduced proliferation in myeloid progenitors from E14.5 livers
decreased spleen weight ( J:223276 )
• at P8 to P10
abnormal hematopoietic stem cell physiology ( J:223276 )
• hematopoietic stem cells fail to reconstitute mice with sterilized bone marrow

growth/size/body
decreased body size ( J:223276 )
• half of wild-type
decreased body weight ( J:223276 )
• half of wild-type

liver/biliary system
small liver ( J:223276 )
• at E14.5
liver hypoplasia ( J:223276 )
• at E14.5

cellular
increased thymocyte apoptosis ( J:223276 )
• thymocytes in the cortical and cortical-medullary junction are apoptotic and accumulate small irregular nuclear fragments

endocrine/exocrine glands
increased thymocyte apoptosis ( J:223276 )
• thymocytes in the cortical and cortical-medullary junction are apoptotic and accumulate small irregular nuclear fragments
decreased thymus weight ( J:223276 )
• at P8 to P10

immune system
increased thymocyte apoptosis ( J:223276 )
• thymocytes in the cortical and cortical-medullary junction are apoptotic and accumulate small irregular nuclear fragments
decreased thymus weight ( J:223276 )
• at P8 to P10
decreased spleen weight ( J:223276 )
• at P8 to P10




Genotype
MGI:5707899
hm2
Allelic
Composition		 Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic
Background		 involves: 129 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps27lGt(IST11658B7)Tigm mutation (1 available); any Rps27l mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:223276 )
• Background Sensitivity: mice on a mixed 129 and C57BL/6 background exhibit 50% lethality at P18 and have a lifespan up to 35 days while mice on a pure C57BL/6 background die within 12 days of birth
postnatal lethality, incomplete penetrance ( J:223276 )
• Background Sensitivity: mice on a mixed 129 and C57BL/6 background exhibit 50% lethality at P18 and have a lifespan up to 35 days while mice on a pure C57BL/6 background die within 12 days of birth

hematopoietic system

endocrine/exocrine glands

immune system




Genotype
MGI:5707902
hm3
Allelic
Composition		 Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic
Background		 involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps27lGt(IST11658B7)Tigm mutation (1 available); any Rps27l mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:223276 )
• mice survive until 5 weeks of age




Genotype
MGI:5707900
cx4
Allelic
Composition		 Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps27lGt(IST11658B7)Tigm mutation (1 available); any Rps27l mutation (20 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:223276 )
N
• postnatal lethality observed in Rps27lGt(IST11658B7)Tigm homozygotes is rescued

neoplasm
increased lymphoma incidence ( J:223276 )
• 50% of mice are dying of lymphoma by 150 days as in Trp53tm1Tyj homozygotes

growth/size/body
growth/size/body region phenotype ( J:223276 )
N
• growth retardation and organ hypocellularity (spleen, thymus and bone marrow) observed in Rps27lGt(IST11658B7)Tigm homozygotes is rescued

hematopoietic system
hematopoietic system phenotype ( J:223276 )
N
• hematopoietic stem cell depletion and hematopoietic failure observed in Rps27lGt(IST11658B7)Tigm homozygotes is rescued




Genotype
MGI:5707901
cx5
Allelic
Composition		 Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Trp53tm1Tyj/Trp53+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps27lGt(IST11658B7)Tigm mutation (1 available); any Rps27l mutation (20 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:223276 )
• 7 of 14 mice develop T-lymphoblastic lymphoma
• 1 of 14 mice develop T-cell lymphoma in thymus, lymph node and spleen

mortality/aging
mortality/aging ( J:223276 )
N
• postnatal lethality observed in Rps27lGt(IST11658B7)Tigm homozygotes is rescued
premature death ( J:223276 )
• mice die sooner than mice with a wild-type allele of Rps271

neoplasm
increased T cell derived lymphoma incidence ( J:223276 )
• 7 of 14 mice develop T-lymphoblastic lymphoma
• 1 of 14 mice develop T-cell lymphoma in thymus, lymph node and spleen

hematopoietic system
increased T cell derived lymphoma incidence ( J:223276 )
• 7 of 14 mice develop T-lymphoblastic lymphoma
• 1 of 14 mice develop T-cell lymphoma in thymus, lymph node and spleen
decreased bone marrow cell number ( J:223276 )
• partially rescued

cellular
aneuploidy ( J:223276 )
• in lymphoma cells and mouse embryonic fibroblasts

growth/size/body
growth/size/body region phenotype ( J:223276 )
N
• growth retardation and organ hypocellularity (spleen, thymus and bone marrow) observed in Rps27lGt(IST11658B7)Tigm homozygotes is rescued
enlarged liver ( J:223276 )
enlarged spleen ( J:223276 )

immune system
increased T cell derived lymphoma incidence ( J:223276 )
• 7 of 14 mice develop T-lymphoblastic lymphoma
• 1 of 14 mice develop T-cell lymphoma in thymus, lymph node and spleen
enlarged lymph nodes ( J:223276 )
• in 1 of 14 mice

liver/biliary system




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory