Phenotypes associated with this allele

• Allele Symbol: Chchd4^{Gt(IST11943B12)Tigm}
• Allele Name: gene trap IST11943B12, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:4038368
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chchd4^Gt(IST11943B12)Tigm/Chchd4^Gt(IST11943B12)Tigm	involves: C57BL/6N	MGI:6278108
ht2	Chchd4^Gt(IST11943B12)Tigm/Chchd4^+	involves: C57BL/6N	MGI:6278109

Genotype
MGI:6278108

hm1

• Allelic Composition: Chchd4^{Gt(IST11943B12)Tigm}/Chchd4^{Gt(IST11943B12)Tigm}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:256078 )

• homozygous embryos exhibit a developmental arrest coupled with embryonic lethality at the onset of gastrulation, with no embryos detected after E8.5

embryo

embryonic growth arrest ( J:256078 )

• homozygous embryos exhibit a developmental arrest at the onset of gastrulation

embryonic growth retardation ( J:256078 )

growth/size/body

embryonic growth retardation ( J:256078 )

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:256078 )

• at E5.5-E6, homozygous embryos show a major defect in the expression of respiratory chain complex I subunit CI-20

Genotype
MGI:6278109

ht2

• Allelic Composition: Chchd4^{Gt(IST11943B12)Tigm}/Chchd4⁺
• Genetic Background: involves: C57BL/6N

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:250035 )

♀ • when fed a Western style high-fat diet starting from 4 weeks of age, heterozygotes exhibit a significantly reduced weight gain compared to age- and sex-matched wild-type controls

♀ • however, no differences in weight gain are observed on a normal chow diet

growth/size/body

decreased susceptibility to diet-induced obesity ( J:250035 )

♀ • when fed a Western style high-fat diet starting from 4 weeks of age, heterozygotes exhibit a significantly reduced weight gain compared to age- and sex-matched wild-type controls

♀ • however, no differences in weight gain are observed on a normal chow diet

mortality/aging

mortality/aging ( J:250035 )

N • heterozygotes have a life expectancy of at least 1.5 years with no apparent pathology

cellular

cellular phenotype ( J:250035 )

N • heterozygotes show no major respiratory chain defects relative to wild-type controls