Phenotypes associated with this allele

• Allele Symbol: Poldip2^{Gt(IST12080D9)Tigm}
• Allele Name: gene trap IST12080D9, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:4044390
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Poldip2^Gt(IST12080D9)Tigm/Poldip2^Gt(IST12080D9)Tigm	involves: C57BL/6N	MGI:5575527
ht2	Poldip2^Gt(IST12080D9)Tigm/Poldip2^+	involves: C57BL/6N	MGI:5575528

Genotype
MGI:5575527

hm1

• Allelic Composition: Poldip2^{Gt(IST12080D9)Tigm}/Poldip2^{Gt(IST12080D9)Tigm}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211022 )

• fewer than expected mice are present at genotyping

growth/size/body

decreased body size ( J:211022 )

• in surviving mice with later weaning

Genotype
MGI:5575528

ht2

• Allelic Composition: Poldip2^{Gt(IST12080D9)Tigm}/Poldip2⁺
• Genetic Background: involves: C57BL/6N

cardiovascular system

abnormal aorta morphology ( J:211022 )

• increased stiffness in maximally dilated aortic ring

abnormal aorta elastic tissue morphology ( J:211022 )

• fragmented and irregular in thickness and orientation of the elastic lamellae with increased in interlamellar area occupied by fibrillar or amorphous extracellular matric

abnormal systemic arterial blood pressure ( J:211022 )

• slight reduction in angiotensin II-induced hypertension

abnormal vasoconstriction ( J:211022 )

• reduced maximal force of phenylephrine- or exogenous potassium chloride-induced aorta contractions whether preincubated with polyethylene glycol-catalase or not

• however, sensitivity to phenylephrine is normal

abnormal vasodilation ( J:211022 )

• mice are protected from CaCl2-induced vascular dilation compared with wild-type mice

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:211022 )

• decreased NADPH-dependent production of O2- and hydrogen peroxide

muscle

abnormal vasoconstriction ( J:211022 )

• reduced maximal force of phenylephrine- or exogenous potassium chloride-induced aorta contractions whether preincubated with polyethylene glycol-catalase or not

• however, sensitivity to phenylephrine is normal

abnormal vasodilation ( J:211022 )

• mice are protected from CaCl2-induced vascular dilation compared with wild-type mice