Analysis Tools|
Allele Symbol Allele Name Allele ID |
Poldip2Gt(IST12080D9)Tigm gene trap IST12080D9, Texas A&M Institute for Genomic Medicine MGI:4044390 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected mice are present at genotyping
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• in surviving mice with later weaning
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased stiffness in maximally dilated aortic ring
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• fragmented and irregular in thickness and orientation of the elastic lamellae with increased in interlamellar area occupied by fibrillar or amorphous extracellular matric
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• slight reduction in angiotensin II-induced hypertension
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• reduced maximal force of phenylephrine- or exogenous potassium chloride-induced aorta contractions whether preincubated with polyethylene glycol-catalase or not
• however, sensitivity to phenylephrine is normal
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• mice are protected from CaCl2-induced vascular dilation compared with wild-type mice
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• decreased NADPH-dependent production of O2- and hydrogen peroxide
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• reduced maximal force of phenylephrine- or exogenous potassium chloride-induced aorta contractions whether preincubated with polyethylene glycol-catalase or not
• however, sensitivity to phenylephrine is normal
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• mice are protected from CaCl2-induced vascular dilation compared with wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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