Phenotypes associated with this allele

• Allele Symbol: Pdlim1^{Gt(IST12013D3)Tigm}
• Allele Name: gene trap IST12013D3, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:4045825
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdlim1^Gt(IST12013D3)Tigm/Pdlim1^Gt(IST12013D3)Tigm	involves: C57BL/6N	MGI:5578593

Genotype
MGI:5578593

hm1

• Allelic Composition: Pdlim1^{Gt(IST12013D3)Tigm}/Pdlim1^{Gt(IST12013D3)Tigm}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:212221 )

N

abnormal platelet physiology ( J:212221 )

• platelets exhibit hyperactivity in response to GPVI agonists compared with wild-type cells

• however, response to GPCR agonists ADP, thrombin and the stable thromboxane A2 analog U46619 is normal

increased platelet aggregation ( J:212221 )

• in response to GPVI agonists

• in platelets on collagen under flow

homeostasis/metabolism

abnormal platelet physiology ( J:212221 )

• platelets exhibit hyperactivity in response to GPVI agonists compared with wild-type cells

• however, response to GPCR agonists ADP, thrombin and the stable thromboxane A2 analog U46619 is normal

increased platelet aggregation ( J:212221 )

• in response to GPVI agonists

• in platelets on collagen under flow

abnormal thrombosis ( J:212221 )

• from platelets perfused with collagen under flow