Phenotypes associated with this allele

• Allele Symbol: Mir142hg^{Gt(IST11580H2)Tigm}
• Allele Name: gene trap IST11580H2, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:4059881
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir142hg^Gt(IST11580H2)Tigm/Mir142hg^Gt(IST11580H2)Tigm	involves: C57BL/6N	MGI:5584114

Genotype
MGI:5584114

hm1

• Allelic Composition: Mir142hg^{Gt(IST11580H2)Tigm}/Mir142hg^{Gt(IST11580H2)Tigm}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:207516 )

N • mice exhibit normal numbers of macrophages and dendritic cell precursors

enlarged spleen ( J:207516 )

• starting at 6 weeks with slight infiltration of secondary and primary lymphoid organs by myeloid cells (particularly neutrophils)

increased neutrophil cell number ( J:207516 )

• neutrophils infiltrate the spleens, skin-draining lymph nodes and thymi

abnormal dendritic cell morphology ( J:207516 )

• distorted dendritic cell composition

abnormal dendritic cell differentiation ( J:207516 )

• cell-intrinsic and cell-specific impairment in generation of CD4+ dendritic cells (determined by bone marrow cell transplantation experiments)

decreased dendritic cell number ( J:207516 )

• 2.5-fold and 1.7-fold reduction in absolute number of CD4+ and CD8alpha+ dendritic cells independent of enlarged spleens

• decreased CD4+ dendritic cells in mesenteric lymph nodes

increased dendritic cell number ( J:207516 )

• increased absolute number of double negative dendritic cells due to splenomegaly

• increased numbers of CD103+ CD11b+ dendritic cell in the mesenteric lymph nodes

• however, the frequency of double negative dendritic cells is normal

hematopoietic system

hematopoietic system phenotype ( J:207516 )

N • mice exhibit normal numbers of macrophages and dendritic cell precursors

enlarged spleen ( J:207516 )

• starting at 6 weeks with slight infiltration of secondary and primary lymphoid organs by myeloid cells (particularly neutrophils)

abnormal definitive hematopoiesis ( J:207516 )

• slight decrease in early myeloid progenitors

increased neutrophil cell number ( J:207516 )

• neutrophils infiltrate the spleens, skin-draining lymph nodes and thymi

abnormal dendritic cell morphology ( J:207516 )

• distorted dendritic cell composition

abnormal dendritic cell differentiation ( J:207516 )

• cell-intrinsic and cell-specific impairment in generation of CD4+ dendritic cells (determined by bone marrow cell transplantation experiments)

decreased dendritic cell number ( J:207516 )

• 2.5-fold and 1.7-fold reduction in absolute number of CD4+ and CD8alpha+ dendritic cells independent of enlarged spleens

• decreased CD4+ dendritic cells in mesenteric lymph nodes

increased dendritic cell number ( J:207516 )

• increased absolute number of double negative dendritic cells due to splenomegaly

• increased numbers of CD103+ CD11b+ dendritic cell in the mesenteric lymph nodes

• however, the frequency of double negative dendritic cells is normal

abnormal bone marrow cell physiology ( J:207516 )

• cell-intrinsic and cell-specific impairment in generation of CD4+ dendritic cells (determined by bone marrow cell transplantation experiments)

• in reconstitution experiments, CD4+ dendritic cells exhibit impaired CD4+ T cell priming compared to control mice

• bone marrow cells fail to develop CD4+ dendritic cells in vitro

cellular

abnormal dendritic cell differentiation ( J:207516 )

• cell-intrinsic and cell-specific impairment in generation of CD4+ dendritic cells (determined by bone marrow cell transplantation experiments)

growth/size/body

enlarged spleen ( J:207516 )

• starting at 6 weeks with slight infiltration of secondary and primary lymphoid organs by myeloid cells (particularly neutrophils)