Phenotypes associated with this allele

• Allele Symbol: Slc47a1^{Gt(IST12634F2)Tigm}
• Allele Name: gene trap IST12634F2, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:4100843
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc47a1^Gt(IST12634F2)Tigm/Slc47a1^Gt(IST12634F2)Tigm	B6.B6N-Slc47a1^Gt(IST12634F2)Tigm	MGI:5555046

Genotype
MGI:5555046

hm1

• Allelic Composition: Slc47a1^{Gt(IST12634F2)Tigm}/Slc47a1^{Gt(IST12634F2)Tigm}
• Genetic Background: B6.B6N-Slc47a1^{Gt(IST12634F2)Tigm}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:206792 )

• following paraquat administration, mice exhibit increased kidney degradation (including tubular dilatation, tubular cell vacuolation and tubular cell detachment from basement membrane) and liver damage (balloon hepatocytes and apoptotic necrotic cells) compared with wild-type mice

abnormal xenobiotic pharmacokinetics ( J:206792 )

• mice exhibit a 6.9- and 3.4-fold accumulation of metformin in the liver and kidney compared with wild-type mice

• following paraquat intravenous administration, mice exhibit higher plasma, lung and renal paraquat concentrations compared with wild-type mice

growth/size/body

increased body weight ( J:206792 )

• modest

liver/biliary system

abnormal liver morphology ( J:206792 )

• liver damage following paraquat administration

renal/urinary system

kidney degeneration ( J:206792 )

• following paraquat administration