Phenotypes associated with this allele

• Allele Symbol: Dapk1^{Gt(IST12766D5)Tigm}
• Allele Name: gene trap IST12766D5, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:4111957
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dapk1^Gt(IST12766D5)Tigm/Dapk1^Gt(IST12766D5)Tigm	C57BL/6-Dapk1^Gt(IST12766D5)Tigm	MGI:4458365

Genotype
MGI:4458365

hm1

• Allelic Composition: Dapk1^{Gt(IST12766D5)Tigm}/Dapk1^{Gt(IST12766D5)Tigm}
• Genetic Background: C57BL/6-Dapk1^{Gt(IST12766D5)Tigm}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:161179 )

N • mice exhibit normal AMPA receptor- and NMDA-receptor mediated excitatory postsynaptic currents and induction of long term potentiation

decreased neuron apoptosis ( J:161179 )

• in response to oxygen/glucose deprivation or NMDA challenge

decreased susceptibility to ischemic brain injury ( J:161179 )

• following occlusion of the common carotid artery, mice exhibit less neuronal death and improved neurological scores compared with similarly treated wild-type mice

decreased cerebral infarct size ( J:161179 )

• following ischemia induced by occlusion of the common carotid artery and reperfusion

reduced NMDA-mediated synaptic currents ( J:161179 )

• in response to oxygen/glucose deprivation or NMDA challenge

homeostasis/metabolism

decreased susceptibility to ischemic brain injury ( J:161179 )

• following occlusion of the common carotid artery, mice exhibit less neuronal death and improved neurological scores compared with similarly treated wild-type mice

decreased cerebral infarct size ( J:161179 )

• following ischemia induced by occlusion of the common carotid artery and reperfusion

cellular

decreased neuron apoptosis ( J:161179 )

• in response to oxygen/glucose deprivation or NMDA challenge