Phenotypes associated with this allele

• Allele Symbol: Ppp2r5a^{Gt(IST13127C10)Tigm}
• Allele Name: gene trap IST13127C10, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:4119929
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppp2r5a^Gt(IST13127C10)Tigm/Ppp2r5a^Gt(IST13127C10)Tigm	C57BL/6N-Ppp2r5a^Gt(IST13127C10)Tigm	MGI:6198728
hm2	Ppp2r5a^Gt(IST13127C10)Tigm/Ppp2r5a^Gt(IST13127C10)Tigm	involves: C57BL/6N * FVB/N	MGI:6198760

Genotype
MGI:6198728

hm1

• Allelic Composition: Ppp2r5a^{Gt(IST13127C10)Tigm}/Ppp2r5a^{Gt(IST13127C10)Tigm}
• Genetic Background: C57BL/6N-Ppp2r5a^{Gt(IST13127C10)Tigm}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

sebaceous gland hyperplasia ( J:254808 )

• outside skin lesions

• hyperproliferation in skin lesions

alopecia ( J:254808 )

• with skin lesions, between ages 11 and 21 months in 28% (5/18) of mice

• in 11% (2/18) of apparently healthy mice at age 22 months

increased hair follicle number ( J:254808 )

• outside skin lesions

• hyperproliferation in skin lesions

dermal hyperplasia ( J:254808 )

• hyperproliferation in skin lesions

• outside skin lesions

epidermal hyperplasia ( J:254808 )

• hyperproliferation in skin lesions

• outside skin lesions

skin lesions ( J:254808 )

• with hair loss, between ages 11 and 21 months in 28% (5/18) of mice

• increased CD3+ T cell infiltration

immune system

enlarged spleen ( J:254808 )

• in 6% (1/18) of apparently healthy mice at age 22 months

• combined with skin lesions in 17% (3/18) of mice

• increased immune cell infiltration

enlarged mesenteric lymph nodes ( J:254808 )

• in 11% (2/18) of apparently healthy mice at age 22 months

• combined with skin lesions in 6% (1/18) of mice

• increased immune cell infiltration

hematopoietic system

enlarged spleen ( J:254808 )

• in 6% (1/18) of apparently healthy mice at age 22 months

• combined with skin lesions in 17% (3/18) of mice

• increased immune cell infiltration

extramedullary hematopoiesis ( J:254808 )

• significantly more colonies formed by whole white blood cells from GM-CSF induced mice in CFU assay compared to wild-type

• 66% increase in c-Kit+ circulating stem cells in peripheral blood mononuclear cells (PBMCs) from GM-CSF induced mice

endocrine/exocrine glands

sebaceous gland hyperplasia ( J:254808 )

• outside skin lesions

• hyperproliferation in skin lesions

liver/biliary system

enlarged liver ( J:254808 )

• combined with skin lesions in 11% (2/18) of mice

• in 6% (1/18) of apparently healthy mice at age 22 months

• increased immune cell infiltration

growth/size/body

enlarged liver ( J:254808 )

• combined with skin lesions in 11% (2/18) of mice

• in 6% (1/18) of apparently healthy mice at age 22 months

• increased immune cell infiltration

enlarged spleen ( J:254808 )

• in 6% (1/18) of apparently healthy mice at age 22 months

• combined with skin lesions in 17% (3/18) of mice

• increased immune cell infiltration

Genotype
MGI:6198760

hm2

• Allelic Composition: Ppp2r5a^{Gt(IST13127C10)Tigm}/Ppp2r5a^{Gt(IST13127C10)Tigm}
• Genetic Background: involves: C57BL/6N * FVB/N

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:254808 )

• earlier appearance of skin papillomas after DMBA/TPA treatment: 53.2 days after TPA treatment start vs 75.6 in wild-type

• total number of papillomas and number of papillomas converted to squamous cell carcinoma (SCC) after 20 weeks of TPA treatment

neoplasm

increased incidence of tumors by chemical induction ( J:254808 )

• earlier appearance of skin papillomas after DMBA/TPA treatment: 53.2 days after TPA treatment start vs 75.6 in wild-type

• total number of papillomas and number of papillomas converted to squamous cell carcinoma (SCC) after 20 weeks of TPA treatment