Phenotypes associated with this allele

• Allele Symbol: Apc^Gt(XA018)Byg
• Allele Name: gene trap XA018, BayGenomics
• Allele ID: MGI:4122552
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Apc^Gt(XA018)Byg/Apc^+	(B6.129P2-Apc^Gt(XA018)Byg x C3H/HeJ)F1	MGI:5522759
ht2	Apc^Gt(XA018)Byg/Apc^+	B6.129P2-Apc^Gt(XA018)Byg	MGI:5522758

Genotype
MGI:5522759

ht1

• Allelic Composition: Apc^Gt(XA018)Byg/Apc⁺
• Genetic Background: (B6.129P2-Apc^Gt(XA018)Byg x C3H/HeJ)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased tumor growth/size ( J:202877 )

• Background Sensitivity: mice with a C57BL6 and C3H/HeJ F1 background exhibit develop fewer polyps than mice in a congenic C57BL/6 background in the small intestine

Genotype
MGI:5522758

ht2

• Allelic Composition: Apc^Gt(XA018)Byg/Apc⁺
• Genetic Background: B6.129P2-Apc^Gt(XA018)Byg

neoplasm

increased intestinal adenoma incidence ( J:202877 )

• small intestine

increased colon adenoma incidence ( J:202877 )

increased tumor growth/size ( J:202877 )

• increased tumor multiplicity and burden of smaller sized tumors/polyps in the distal small intestine compared with Apc^Min heterozygotes

• Background Sensitivity: mice on a congenic C57BL/6 background develop more polyps than mice with a C57BL6 and C3H/HeJ F1 background

• however, tumor pathology is the same as in Apc^Min heterozygotes

digestive/alimentary system

increased intestinal adenoma incidence ( J:202877 )

• small intestine

increased colon adenoma incidence ( J:202877 )

intestine polyps ( J:202877 )

• increased tumor multiplicity and burden of smaller sized tumors/polyps in the small intestine compared with Apc^Min heterozygotes