About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nme2Gt(69C10)Cmhd
gene trap 69C10, Centre for Modeling Human Disease
MGI:4122609
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nme2Gt(69C10)Cmhd/Nme2Gt(69C10)Cmhd B6.129-Nme2Gt(69C10)Cmhd MGI:4868386


Genotype
MGI:4868386
hm1
Allelic
Composition		 Nme2Gt(69C10)Cmhd/Nme2Gt(69C10)Cmhd
Genetic
Background		 B6.129-Nme2Gt(69C10)Cmhd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nme2Gt(69C10)Cmhd mutation (0 available); any Nme2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:167387 )
N
• mice exhibit normal T cell-dependent antigen response
abnormal CD4-positive, alpha-beta T cell physiology ( J:167387 )
• Th0 cells exhibit impaired KCa3.1 channel activity compared with wild-type mice
• however, Th17 function is normal
abnormal T-helper 1 physiology ( J:167387 )
• Th1 cells exhibit decreased KCa3.1 channel activity and defective TCR-stimulated calcium ion flux and cytokine (IFN-gamma, IL2, and TNFalpha) production compared with wild-type mice
abnormal T-helper 2 physiology ( J:167387 )
• Th2 cells exhibit decreased KCa3.1 channel activity and defective TCR-stimulated calcium ion flux and cytokine (IL13 and TNFalpha) production compared with wild-type mice
decreased interferon-gamma secretion ( J:167387 )
• in TCR-stimulated Th1 cells
decreased interleukin-13 secretion ( J:167387 )
• in TCR-stimulated Th2 cells
decreased interleukin-2 secretion ( J:167387 )
• in TCR-stimulated Th1 cells
decreased tumor necrosis factor secretion ( J:167387 )
• in TCR-stimulated Th1 and Th2 cells

hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:167387 )
• Th0 cells exhibit impaired KCa3.1 channel activity compared with wild-type mice
• however, Th17 function is normal
abnormal T-helper 1 physiology ( J:167387 )
• Th1 cells exhibit decreased KCa3.1 channel activity and defective TCR-stimulated calcium ion flux and cytokine (IFN-gamma, IL2, and TNFalpha) production compared with wild-type mice
abnormal T-helper 2 physiology ( J:167387 )
• Th2 cells exhibit decreased KCa3.1 channel activity and defective TCR-stimulated calcium ion flux and cytokine (IL13 and TNFalpha) production compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory