Analysis Tools
mortality/aging
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• mice do not survive beyond E8.5
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embryo
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• after 7 days in culture, most blastocysts exhibit impaired growth of inner cell masse unlike wild-type blastocyst
• however, giant trophoblast cells develop normally
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• at E7.5, mice exhibit an enhanced accumulation of blood sinus at the antimesometrial pole compared with wild-type mice
• at E7.5, mice exhibit an accumulation of a mass of cells and cavities do not form unlike in wild-type mice
• at E8.5, mice lack normal morphological structures observed in wild-type mice
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• at E7.5 and E8.5
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• at E6.5, at E7.5, and further at E8.5
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• embryonic stem cells could not be isolated unlike in wild-type mice
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• at E9.5, mice are encased in a spherical structure formed by yolk sac and amnion and completely void of normal morphology compared with wild-type mice
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• at E7.5, allantois exhibit an increase in mass of cells compared with wild-type mice
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• undetectable at E7.5
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• at E9.5, yolk sacs exhibit a condensed mass of cell without detectable blood vessels unlike wild-type mice
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growth/size/body
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• at E7.5 and E8.5
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• at E6.5, at E7.5, and further at E8.5
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cardiovascular system
cellular
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• after 7 days in culture, most blastocysts exhibit impaired growth of inner cell masse unlike wild-type blastocyst
• however, giant trophoblast cells develop normally
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