Phenotypes associated with this allele

• Allele Symbol: Stoml1^{Gt(M038E05)Wrst}
• Allele Name: gene trap M038E05, German Gene Trap Consortium
• Allele ID: MGI:4122966
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stoml1^Gt(M038E05)Wrst/Stoml1^Gt(M038E05)Wrst	B6.129S2-Stoml1^Gt(M038E05)Wrst	MGI:5662089

Genotype
MGI:5662089

hm1

• Allelic Composition: Stoml1^{Gt(M038E05)Wrst}/Stoml1^{Gt(M038E05)Wrst}
• Genetic Background: B6.129S2-Stoml1^{Gt(M038E05)Wrst}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system electrophysiology ( J:219161 )

• whole-cell electrophysiology recordings from mutant DRG neurons show on average larger proton-gated currents relative to wild-type neurons, due to a contribution of effects upon both transient (ASIC-like) and sustained (non-ASIC-like) currents, at different pH

• in mutant DRG neurons, sustained currents are significantly greater at pH 5.0 and 4.0, but not at pH 6.0, relative to wild-type neurons

• transient currents are significantly greater at pH 6.0, but not at lower pH values

• transient currents in mutant DRG neurons inactivate significantly more rapidly at pH 4.0, but not at pH 5.0

• no significant differences are observed in the magnitude of either ATP-activated or voltage-gated inward currents

behavior/neurological

behavior/neurological phenotype ( J:219161 )

N • homozygotes are viable and display no overt neurological phenotypes