Phenotypes associated with this allele

• Allele Symbol: Snx5^Gt(XA155)Byg
• Allele Name: gene trap XA155, BayGenomics
• Allele ID: MGI:4123839
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Snx5^Gt(XA155)Byg/Snx5^Gt(XA155)Byg	B6.129P2-Snx5^Gt(XA155)Byg	MGI:5514059

Genotype
MGI:5514059

hm1

• Allelic Composition: Snx5^Gt(XA155)Byg/Snx5^Gt(XA155)Byg
• Genetic Background: B6.129P2-Snx5^Gt(XA155)Byg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Growth retardation phenotype in Snx5^Gt(XA155)Byg/Snx5^Gt(XA155)Byg mice at P30

mortality/aging

perinatal lethality, incomplete penetrance ( J:199909 )

• although present in Mendelian ratios at E17.5, fewer than expected mice are born

neonatal lethality, incomplete penetrance ( J:199909 )

• some mice die within the first 24 hours after birth

postnatal lethality, incomplete penetrance ( J:199909 )

• some mice die within the first month after birth

respiratory system

decreased lung weight ( J:199909 )

• slightly at E18.5

abnormal pulmonary alveolar sac morphology ( J:199909 )

• reduced air spaces at E18.5

abnormal pulmonary alveolus morphology ( J:199909 )

• impaired formation with thickened alveolar walls and reduced air spaces at E18.5

• however, mice exhibit normal alveolar walls and air space at E14.5 and E16.5 and maturation of alveolar epithelial type II cells

decreased type I pneumocyte number ( J:199909 )

• due to impaired differentiation

primary atelectasis ( J:199909 )

• in most newborn mice

• however, some mice exhibit partially inflated lungs

respiratory failure ( J:199909 )

• at birth in some mice

growth/size/body

decreased body size ( J:199909 )

• in surviving mice

decreased body weight ( J:199909 )

• at P21 and P30

postnatal growth retardation ( J:199909 )

homeostasis/metabolism

cyanosis ( J:199909 )

• most newborn mice

integument

abnormal coat/hair pigmentation ( J:199909 )

• despite backcross to C57BL/6 (non-agouti) 5 times, mice exhibit a white-bellied agouti coat color possibly due to tight linkage (6cM) with Agouti from the 129P2/OlaHsd ES cells

pigmentation

abnormal coat/hair pigmentation ( J:199909 )

• despite backcross to C57BL/6 (non-agouti) 5 times, mice exhibit a white-bellied agouti coat color possibly due to tight linkage (6cM) with Agouti from the 129P2/OlaHsd ES cells