Phenotypes associated with this allele

• Allele Symbol: Trim71^Gt(XA144)Byg
• Allele Name: gene trap XA144, BayGenomics
• Allele ID: MGI:4123844
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim71^Gt(XA144)Byg/Trim71^Gt(XA144)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:4357769

Genotype
MGI:4357769

hm1

• Allelic Composition: Trim71^Gt(XA144)Byg/Trim71^Gt(XA144)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:152121 )

• no mice are present at E16.5

embryonic lethality during organogenesis, incomplete penetrance ( J:152121 )

• only 15.6% of embryos are recovered between E9.0 and E9.5

nervous system

everted embryonic neuroepithelium ( J:152121 )

• open neural folds are everted, enlarged and fail to fuse

incomplete rostral neuropore closure ( J:152121 )

• anterior neural tube closure defects resulting in exencephaly (100% penetrance)

• complete neural tube closure in the posterior spinal region

decreased brain size ( J:152121 )

• at E14.5

abnormal brain ventricle morphology ( J:152121 )

• at E11.5, brain ventricles are not correctly located as in wild-type mice

absent lateral ventricles ( J:152121 )

• lateral ventricles are undetectable at E12.5, most likely due to open neural tube defect

exencephaly ( J:152121 )

• at E11.5, brain tissue is exposed unlike in wild-type mice

craniofacial

abnormal nose morphology ( J:152121 )

• the nasal process is abnormal

facial cleft ( J:152121 )

• mice exhibit possible clefting of the facial prominence

cardiovascular system

hemorrhage ( J:152121 )

• at E13.5, mice exhibit blood pooling

growth/size/body

abnormal nose morphology ( J:152121 )

• the nasal process is abnormal

facial cleft ( J:152121 )

• mice exhibit possible clefting of the facial prominence

decreased fetal size ( J:152121 )

• at E14.5

respiratory system

abnormal nose morphology ( J:152121 )

• the nasal process is abnormal

embryo

everted embryonic neuroepithelium ( J:152121 )

• open neural folds are everted, enlarged and fail to fuse

incomplete rostral neuropore closure ( J:152121 )

• anterior neural tube closure defects resulting in exencephaly (100% penetrance)

• complete neural tube closure in the posterior spinal region

integument

pallor ( J:152121 )

• at E14.5