Phenotypes associated with this allele

• Allele Symbol: Lman1^{Gt(XST010)Byg}
• Allele Name: gene trap XST010, BayGenomics
• Allele ID: MGI:4123879
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lman1^Gt(XST010)Byg/Lman1^Gt(XST010)Byg	129S1.129P2-Lman1^Gt(XST010)Byg	MGI:5296771
hm2	Lman1^Gt(XST010)Byg/Lman1^Gt(XST010)Byg	A.129P2-Lman1^Gt(XST010)Byg	MGI:5296773
hm3	Lman1^Gt(XST010)Byg/Lman1^Gt(XST010)Byg	B6.129-Lman1^Gt(XST010)Byg	MGI:6195537
hm4	Lman1^Gt(XST010)Byg/Lman1^Gt(XST010)Byg	B6.129P2-Lman1^Gt(XST010)Byg	MGI:5296770
hm5	Lman1^Gt(XST010)Byg/Lman1^Gt(XST010)Byg	D2.129P2-Lman1^Gt(XST010)Byg	MGI:5296772
hm6	Lman1^Gt(XST010)Byg/Lman1^Gt(XST010)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:5296774
cx7	Lman1^Gt(XST010)Byg/Lman1^Gt(XST010)Byg Mcfd2^tm1Dgi/Mcfd2^tm1Dgi	B6.129-Mcfd2^tm1Dgi Lman1^Gt(XST010)Byg	MGI:6195535

Genotype
MGI:5296771

hm1

• Allelic Composition: Lman1^{Gt(XST010)Byg}/Lman1^{Gt(XST010)Byg}
• Genetic Background: 129S1.129P2-Lman1^{Gt(XST010)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:177067 )

• Background Sensitivity: fewer than expected mice are present at weaning unlike on a mixed background

Genotype
MGI:5296773

hm2

• Allelic Composition: Lman1^{Gt(XST010)Byg}/Lman1^{Gt(XST010)Byg}
• Genetic Background: A.129P2-Lman1^{Gt(XST010)Byg}

mortality/aging

mortality/aging ( J:177067 )

N • Background Sensitivity: mice exhibit normal survival unlike on a congenic 129S1, C57BL/6, or DBA/2 background

Genotype
MGI:6195537

hm3

• Allelic Composition: Lman1^{Gt(XST010)Byg}/Lman1^{Gt(XST010)Byg}
• Genetic Background: B6.129-Lman1^{Gt(XST010)Byg}

mortality/aging

lethality, incomplete penetrance ( J:262681 )

• fewer than expected mice are present

homeostasis/metabolism

abnormal protein level ( J:262681 )

• increased factor V and aspartate transaminase levels in the liver with retention in the ER

abnormal circulating protein level ( J:262681 )

• decreased factor V and VIII serum levels

decreased circulating aspartate transaminase level ( J:262681 )

♂ • small decrease in male, but not female, mice with accumulation in the ER

decreased circulating factor VIII level ( J:262681 )

Genotype
MGI:5296770

hm4

• Allelic Composition: Lman1^{Gt(XST010)Byg}/Lman1^{Gt(XST010)Byg}
• Genetic Background: B6.129P2-Lman1^{Gt(XST010)Byg}

mortality/aging

postnatal lethality, incomplete penetrance ( J:177067 )

• Background Sensitivity: despite normal numbers at E18.5, only one-third of expected mice are present at weaning unlike on a mixed background

cellular

cellular phenotype ( J:177067 )

N • COPII-coated vesicle formation in mouse embryonic fibroblasts is normal

abnormal endoplasmic reticulum morphology ( J:177067 )

• slightly dilated in hepatocytes

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:177067 )

N • mice exhibit normal bleeding time

Genotype
MGI:5296772

hm5

• Allelic Composition: Lman1^{Gt(XST010)Byg}/Lman1^{Gt(XST010)Byg}
• Genetic Background: D2.129P2-Lman1^{Gt(XST010)Byg}

mortality/aging

preweaning lethality, incomplete penetrance ( J:177067 )

• Background Sensitivity: fewer than expected mice are present at weaning unlike on a mixed background

Genotype
MGI:5296774

hm6

• Allelic Composition: Lman1^{Gt(XST010)Byg}/Lman1^{Gt(XST010)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

mortality/aging ( J:177067 )

N • Background Sensitivity: mice exhibit normal survival unlike on a congenic 129S1, C57BL/6, or DBA/2 background

Genotype
MGI:6195535

cx7

• Allelic Composition: Lman1^{Gt(XST010)Byg}/Lman1^{Gt(XST010)Byg}; Mcfd2^tm1Dgi/Mcfd2^tm1Dgi
• Genetic Background: B6.129-Mcfd2^tm1Dgi Lman1^{Gt(XST010)Byg}

homeostasis/metabolism

abnormal protein level ( J:262681 )

• increased factor V and aspartate transaminase levels in the liver with retention in the ER

abnormal circulating protein level ( J:262681 )

• decreased factor V and VIII serum levels but not as much as in Mcfd2^tm1Dgi homozygotes

decreased circulating aspartate transaminase level ( J:262681 )

♂ • small decrease in male, but not female, mice with accumulation in the ER

decreased circulating factor VIII level ( J:262681 )