Analysis Tools
adipose tissue
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• mutants fed a high-fat diet exhibit a lower ATP content in brown adipose tissue (BAT)
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• mutants fed a high-fat diet exhibit an increase in brown adipocytes in the interscapular BAT
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growth/size/body
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• mutants fed a regular-chow diet tend to have lower body weights compared to controls
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• mutants fed a high-fat diet are protected from diet-induced obesity compared to wild-type mice; mutants weight less and have lower body fat
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homeostasis/metabolism
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• mutants fed a high-fat diet are protected from diet-induced obesity compared to wild-type mice; mutants weight less and have lower body fat
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• mutants fed a high-fat diet exhibit enhanced adaption to cold challenges and a lesser decrease in body temperatures compared to wild-type mice
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• mutants fed a high-fat diet, but not on a regular chow-diet, exhibit lower baseline serum glucose levels than wild-type mice
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• mutants fed a high-fat diet exhibit enhanced glucose tolerance compared to wild-type mice during IPGTT
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• mutants fed a high-fat diet exhibit enhanced adipose tissue and hepatic insulin sensitivity compared to wild-type mice on the same diet
• - mutants fed a high-fat diet undergoing intraperitoneal glucose tolerance test (IPGTT) display reduced serum insulin responses despite lower serum glucose levels, indicating higher insulin sensitivity compared to wild-type mice
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• mutants fed a high-fat diet show a 1.2-fold increase in serum adiponectin levels compared to wild-type mice
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• mutants fed a high-fat diet exhibit lower hepatic fat and hepatic triglyceride contents
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liver/biliary system
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• mutants fed a high-fat diet exhibit lower hepatic fat and hepatic triglyceride contents
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• mutants fed a high-fat diet exhibit lower hepatic fat and hepatic triglyceride contents
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• mutants on a high-fat diet exhibit reduced endogenous hepatic glucose output
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