About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kcnk5Gt(KST024)Byg
gene trap KST024, BayGenomics
MGI:4123942
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kcnk5Gt(KST024)Byg/Kcnk5Gt(KST024)Byg B6.129P2-Kcnk5Gt(KST024)Byg MGI:4437574
cx2
Kcnk5Gt(KST024)Byg/Kcnk5+
Phox2btm2Jbr/Phox2b+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:4437575


Genotype
MGI:4437574
hm1
Allelic
Composition
Kcnk5Gt(KST024)Byg/Kcnk5Gt(KST024)Byg
Genetic
Background
B6.129P2-Kcnk5Gt(KST024)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnk5Gt(KST024)Byg mutation (0 available); any Kcnk5 mutation (62 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• the CO2 threshold to increase ventilation is reduced to 1% and the normal biphasic response is absent
• long term hypoxia (8% or 10% O2) induced respiratory depression is abolished

nervous system
• brainstem respiratory like activity is decreased by metabolic alkalosis and anoxia, rather than being increased as in controls




Genotype
MGI:4437575
cx2
Allelic
Composition
Kcnk5Gt(KST024)Byg/Kcnk5+
Phox2btm2Jbr/Phox2b+
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcnk5Gt(KST024)Byg mutation (0 available); any Kcnk5 mutation (62 available)
Phox2btm2Jbr mutation (0 available); any Phox2b mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• retrotrapezoid nucleus neurons are absent





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory