About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Glg1Gt(KST005)Byg
gene trap KST005, BayGenomics
MGI:4123950
Summary 5 genotypes


Genotype
MGI:4430495
hm1
Allelic
Composition		 Glg1Gt(KST005)Byg/Glg1Gt(KST005)Byg
Genetic
Background		 B6.129P2-Glg1Gt(KST005)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glg1Gt(KST005)Byg mutation (1 available); any Glg1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:157157 )
• only a few survive to 3 weeks of age
postnatal lethality, incomplete penetrance ( J:157157 )
• 90% of mice died within 2 days after birth
• only a few survive to 3 weeks of age

growth/size/body
abnormal maxillary shelf morphology ( J:157157 )
• incomplete fusion of maxillary shelves in neonates with cleft palate
cleft palate ( J:157157 )
• about 30% of mice, including all of the mice with a bloated abdomen, have a cleft palate
meteorism ( J:157157 )
• bloated abdomen filled with air in 19% of mice
decreased body size ( J:157157 )
• in the few surviving adults
decreased body weight ( J:157157 )
• in the few surviving adults
decreased fetal size ( J:157157 )
• at E18.5
decreased fetal weight ( J:157157 )
• at E18.5

craniofacial
abnormal maxillary shelf morphology ( J:157157 )
• incomplete fusion of maxillary shelves in neonates with cleft palate
cleft palate ( J:157157 )
• about 30% of mice, including all of the mice with a bloated abdomen, have a cleft palate

digestive/alimentary system
abnormal maxillary shelf morphology ( J:157157 )
• incomplete fusion of maxillary shelves in neonates with cleft palate
cleft palate ( J:157157 )
• about 30% of mice, including all of the mice with a bloated abdomen, have a cleft palate
meteorism ( J:157157 )
• bloated abdomen filled with air in 19% of mice

limbs/digits/tail
abnormal tail morphology ( J:157157 )
• tails of all E18.5 embryos and neonates are distorted
abnormal caudal vertebrae morphology ( J:157157 )
• staining of bones and cartilages revealed that tail skeletons of neonates are distorted

skeleton
abnormal maxillary shelf morphology ( J:157157 )
• incomplete fusion of maxillary shelves in neonates with cleft palate
abnormal caudal vertebrae morphology ( J:157157 )
• staining of bones and cartilages revealed that tail skeletons of neonates are distorted
abnormal intervertebral disk morphology ( J:157157 )
• staining of bones and cartilages revealed that tail skeletons of neonates are distorted
• irregular arrangement of the tail cartilages




Genotype
MGI:4430501
cx2
Allelic
Composition		 Fgf18tm1Sjt/Fgf18tm1Sjt
Glg1Gt(KST005)Byg/Glg1+
Genetic
Background		 B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf18tm1Sjt mutation (0 available); any Fgf18 mutation (10 available)
Glg1Gt(KST005)Byg mutation (1 available); any Glg1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

skeleton
abnormal rib morphology ( J:157157 )
• mice die at birth




Genotype
MGI:4430499
cx3
Allelic
Composition		 Fgf18tm1Sjt/Fgf18+
Glg1Gt(KST005)Byg/Glg1Gt(KST005)Byg
Genetic
Background		 B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf18tm1Sjt mutation (0 available); any Fgf18 mutation (10 available)
Glg1Gt(KST005)Byg mutation (1 available); any Glg1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:157157 )
• mortality is similar to Glg1 single mutants

limbs/digits/tail
abnormal tail morphology ( J:157157 )
• tails of neonates are distorted

skeleton
abnormal skeleton morphology ( J:157157 )
• skeletal deformities are similar to those in Glg1 single mutants




Genotype
MGI:4430496
cx4
Allelic
Composition		 Fgf18tm1Sjt/Fgf18+
Glg1Gt(KST005)Byg/Glg1+
Genetic
Background		 B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf18tm1Sjt mutation (0 available); any Fgf18 mutation (10 available)
Glg1Gt(KST005)Byg mutation (1 available); any Glg1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:157157 )
• males are smaller at 1 month and females are smaller by 3 months

limbs/digits/tail
abnormal tail morphology ( J:157157 )
• males are smaller at 1 month and females are smaller by 3 months




Genotype
MGI:4430497
cx5
Allelic
Composition		 Fgf18tm1Sjt/Fgf18tm1Sjt
Glg1Gt(KST005)Byg/Glg1Gt(KST005)Byg
Genetic
Background		 B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf18tm1Sjt mutation (0 available); any Fgf18 mutation (10 available)
Glg1Gt(KST005)Byg mutation (1 available); any Glg1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

limbs/digits/tail
abnormal tail morphology ( J:157157 )
• tails of neonates are distorted

skeleton
abnormal rib morphology ( J:157157 )
• mice die at birth
abnormal spine curvature ( J:157157 )
• more severe curvature of the spine than Fgf18 null alone




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory