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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Glg1Gt(KST005)Byg
gene trap KST005, BayGenomics
MGI:4123950
Summary 5 genotypes


Genotype
MGI:4430495
hm1
Allelic
Composition		 Glg1Gt(KST005)Byg/Glg1Gt(KST005)Byg
Genetic
Background		 B6.129P2-Glg1Gt(KST005)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glg1Gt(KST005)Byg mutation (1 available); any Glg1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:157157 )
• only a few survive to 3 weeks of age
postnatal lethality, incomplete penetrance ( J:157157 )
• 90% of mice died within 2 days after birth
• only a few survive to 3 weeks of age

growth/size/body
abnormal maxillary shelf morphology ( J:157157 )
• incomplete fusion of maxillary shelves in neonates with cleft palate
cleft palate ( J:157157 )
• about 30% of mice, including all of the mice with a bloated abdomen, have a cleft palate
meteorism ( J:157157 )
• bloated abdomen filled with air in 19% of mice
decreased body size ( J:157157 )
• in the few surviving adults
decreased body weight ( J:157157 )
• in the few surviving adults
decreased fetal size ( J:157157 )
• at E18.5
decreased fetal weight ( J:157157 )
• at E18.5

craniofacial
abnormal maxillary shelf morphology ( J:157157 )
• incomplete fusion of maxillary shelves in neonates with cleft palate
cleft palate ( J:157157 )
• about 30% of mice, including all of the mice with a bloated abdomen, have a cleft palate

digestive/alimentary system
abnormal maxillary shelf morphology ( J:157157 )
• incomplete fusion of maxillary shelves in neonates with cleft palate
cleft palate ( J:157157 )
• about 30% of mice, including all of the mice with a bloated abdomen, have a cleft palate
meteorism ( J:157157 )
• bloated abdomen filled with air in 19% of mice

limbs/digits/tail
abnormal tail morphology ( J:157157 )
• tails of all E18.5 embryos and neonates are distorted
abnormal caudal vertebrae morphology ( J:157157 )
• staining of bones and cartilages revealed that tail skeletons of neonates are distorted

skeleton
abnormal maxillary shelf morphology ( J:157157 )
• incomplete fusion of maxillary shelves in neonates with cleft palate
abnormal caudal vertebrae morphology ( J:157157 )
• staining of bones and cartilages revealed that tail skeletons of neonates are distorted
abnormal intervertebral disk morphology ( J:157157 )
• staining of bones and cartilages revealed that tail skeletons of neonates are distorted
• irregular arrangement of the tail cartilages




Genotype
MGI:4430501
cx2
Allelic
Composition		 Fgf18tm1Sjt/Fgf18tm1Sjt
Glg1Gt(KST005)Byg/Glg1+
Genetic
Background		 B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf18tm1Sjt mutation (0 available); any Fgf18 mutation (10 available)
Glg1Gt(KST005)Byg mutation (1 available); any Glg1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

skeleton
abnormal rib morphology ( J:157157 )
• mice die at birth




Genotype
MGI:4430499
cx3
Allelic
Composition		 Fgf18tm1Sjt/Fgf18+
Glg1Gt(KST005)Byg/Glg1Gt(KST005)Byg
Genetic
Background		 B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf18tm1Sjt mutation (0 available); any Fgf18 mutation (10 available)
Glg1Gt(KST005)Byg mutation (1 available); any Glg1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:157157 )
• mortality is similar to Glg1 single mutants

limbs/digits/tail
abnormal tail morphology ( J:157157 )
• tails of neonates are distorted

skeleton
abnormal skeleton morphology ( J:157157 )
• skeletal deformities are similar to those in Glg1 single mutants




Genotype
MGI:4430496
cx4
Allelic
Composition		 Fgf18tm1Sjt/Fgf18+
Glg1Gt(KST005)Byg/Glg1+
Genetic
Background		 B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf18tm1Sjt mutation (0 available); any Fgf18 mutation (10 available)
Glg1Gt(KST005)Byg mutation (1 available); any Glg1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:157157 )
• males are smaller at 1 month and females are smaller by 3 months

limbs/digits/tail
abnormal tail morphology ( J:157157 )
• males are smaller at 1 month and females are smaller by 3 months




Genotype
MGI:4430497
cx5
Allelic
Composition		 Fgf18tm1Sjt/Fgf18tm1Sjt
Glg1Gt(KST005)Byg/Glg1Gt(KST005)Byg
Genetic
Background		 B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf18tm1Sjt mutation (0 available); any Fgf18 mutation (10 available)
Glg1Gt(KST005)Byg mutation (1 available); any Glg1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

limbs/digits/tail
abnormal tail morphology ( J:157157 )
• tails of neonates are distorted

skeleton
abnormal rib morphology ( J:157157 )
• mice die at birth
abnormal spine curvature ( J:157157 )
• more severe curvature of the spine than Fgf18 null alone




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory