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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Notch2Gt(LST103)Byg
gene trap LST103, BayGenomics
MGI:4123984
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Notch2Gt(LST103)Byg/Notch2+
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg 		involves: 129P2/OlaHsd MGI:4418249


Genotype
MGI:4418249
cx1
Allelic
Composition		 Notch2Gt(LST103)Byg/Notch2+
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2Gt(LST103)Byg mutation (0 available); any Notch2 mutation (99 available)
Notch3Gt(PST033)Byg mutation (0 available); any Notch3 mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:155893 )
• mice die shortly after birth

respiratory system
abnormal lung development ( J:155893 )
• myofibroblasts in the lungs exhibit reduced differentiation, as determined by sma+ expression, compared to in wild-type mice
impaired lung alveolus development ( J:155893 )
• 3 of 6 surviving mice exhibit altered alveolar development compared to wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory